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  • 1
    Electronic Resource
    Electronic Resource
    Loss of parvalbumin immunoreactivity defines selectively vulnerable thalamic reticular nucleus neurons following cardiac arrest in the rat (1995)
    Springer
    Acta neuropathologica 89 (1995), S. 262-269 
    Details
    ISSN: 1432-0533
    Keywords: Calcium binding proteins ; Global cerebral ischemia ; Immunocytochemistry ; Selective vulnerability ; Thalamic reticular nucleus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The thalamic reticular nucleus (NRT) is one of the most vulnerable structures to selective neuronal damage both in human cardiac arrest patients and in experimental rodent global cerebral ischemia models. The detailed distribution of neuronal injury within the NRT was examined following 10-min cardiac arrest in the rat with conventional Nissl staining, 45Ca autoradiography and immunocytochemistry of the calcium binding proteins parvalbumin (PV) and calretinin (CR). While Nissl staining was almost unable to show the exact boundary of the nucleus and of the lesion, immunocytochemistry of PV proved to be the most useful index of the exact location and extent of neuronal loss in the NRT after ischemia. Calcium autoradiography was a sensitive method for detecting the lesion, and showed a similar distribution to the loss of PV staining, but did not give optimal spatial resolution. Quantitative analysis of PV staining at 7 days of recirculation demonstrated cell loss restricted to the lateral aspect of the middle segment of the NRT, identical with the distribution of large fusiform neurons in the somatosensory component of the nucleus. CR-positive neurons in the NRT were completely spared, although not all surviving neurons contained CR. These studies provide the first detailed characterization of the distribution of vulnerable neurons within the NRT after experimental ischemia and suggest that immunocytochemistry of PV is a useful tool for quantitative analysis of the lesion for use in further experiments to elucidate the mechanisms of selective vulnerability of the NRT.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00309342
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Loss of parvalbumin immunoreactivity defines selectively vulnerable thalamic reticular nucleus neurons following cardiac arrest in the rat (1995)
    Springer
    Acta neuropathologica 89 (1995), S. 262-269 
    Details
    ISSN: 1432-0533
    Keywords: Key words Calcium binding proteins ; Global ; cerebral ischemia ; Immunocytochemistry ; Selective ; vulnerability ; Thalamic reticular nucleus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The thalamic reticular nucleus (NRT) is one of the most vulnerable structures to selective neuronal damage both in human cardiac arrest patients and in experimental rodent global cerebral ischemia models. The detailed distribution of neuronal injury within the NRT was examined following 10-min cardiac arrest in the rat with conventional Nissl staining, 45Ca autoradiography and immunocytochemistry of the calcium binding proteins parvalbumin (PV) and calretinin (CR). While Nissl staining was almost unable to show the exact boundary of the nucleus and of the lesion, immunocytochemistry of PV proved to be the most useful index of the exact location and extent of neuronal loss in the NRT after ischemia. Calcium autoradiography was a sensitive method for detecting the lesion, and showed a similar distribution to the loss of PV staining, but did not give optimal spatial resolution. Quantitative analysis of PV staining at 7 days of recirculation demonstrated cell loss restricted to the lateral aspect of the middle segment of the NRT, identical with the distribution of large fusiform neurons in the somatosensory component of the nucleus. CR-positive neurons in the NRT were completely spared, although not all surviving neurons contained CR. These studies provide the first detailed characterization of the distribution of vulnerable neurons within the NRT after experimental ischemia and suggest that immunocytochemistry of PV is a useful tool for quantitative analysis of the lesion for use in further experiments to elucidate the mechanisms of selective vulnerability of the NRT.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00309342
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Glycogen accumulation in spinal cord motor neurons due to partial ischemia (1972)
    Springer
    Acta neuropathologica 20 (1972), S. 335-347 
    Details
    ISSN: 1432-0533
    Keywords: Spinal Cord Ischemia ; Neurons ; Glycogen ; UDPG-transferase ; Glycogen Phosphorylase ; Histochemistry ; Electron Microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Partial ischemia of the spinal cord in adult cats was induced by abdominal aortic ligation. The most striking abnormality was an accumulation of glycogen in large motor neurons and astroglia in the peripheral anterior horns. Little or no histological and ultrastructural abnormalities were present in these regions. The first glycogen deposits appeared after 1/2 h in glial cells, whereas glycogen accumulation in neurons was first noticeable 1 h after ligation reaching a maximum in 24 h. A gradual decrease occurred with disappearance of glycogen at 10 days. Increase in UDPG-transferase was found preceeding glycogen appearance, and increase in glycogen-phosphorylase activity occurred later concurrent with glycogen accumulation. This unique neuronal glycogen deposition may be due to the UDPG-transferase normally present in γ-motor neurons of the anterior horns. Other possible mechanisms are also considered.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00691750
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    Glycogen reaction to cerebral stab wound during maturation of rat brain (1972)
    Springer
    Acta neuropathologica 22 (1972), S. 158-169 
    Details
    ISSN: 1432-0533
    Keywords: Brain Stab Wound ; Glycogen Reaction ; Histochemistry ; Electron Microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Abnormal accumulation of glycogen around cerebral stab wounds was studied histochemically, electron microscopically, and quantitatively in rats 4, 13, 28 days old and in adult (90–150 days old) animals. Glycogen did not accumulate around stab wounds in 4 and in 13-day old rats, whereas a considerable accumulation of glycogen was present in the 28 day and in adult animals. There was a close parallelism between the amount of glycogen accumulated and the degree of maturation of oxidative enzyme activity as reflected by succinic dehydrogenase activity in the cortex. In 28 day and in adult animals, a pale central necrotic core was surrounded by a zone of reduced enzyme activity. The region of glycogen accumulation was located peripherally to this zone.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00688782
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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