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  • 1
    Electronic Resource
    Electronic Resource
    Rhabdomyosarcoma in the region of the sella turcica (1987)
    Springer
    Acta neurochirurgica 88 (1987), S. 142-146 
    Details
    ISSN: 0942-0940
    Keywords: Electron microscopy ; immunohistochemistry ; pituitary ; rhabdomyosarcoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Intracranial extension of rhabdomyosarcoma from the face, nasopharynx or middle ear is rare. A 16-year-old boy presented with deterioration of vision and headache. CT scan revealed a soft tissue mass occupying the sphenoid and ethmoid sinuses, extending to the suprasellar fossa and impinging on the optic chiasm. The tumour, mimicking pituitary carcinoma, was removed by transsphenoidal craniotomy. Morphologic studies, including immunohistochemistry and electron microscopy, revealed that the tumour was a rhabdomyosarcoma. This case stresses the value of immunohistochemical and ultrastructural studies in the diagnosis of tumours occurring in the region of the sella turcica. The origin of this tumour was thought to be the sphenoid or ethmoid sinus. The pituitary gland appeared intact.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01404151
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Pituitary growth hormone cell adenoma with cytoplasmic tubular aggregates in the capillary endothelium (1977)
    Springer
    Acta neuropathologica 37 (1977), S. 77-79 
    Details
    ISSN: 1432-0533
    Keywords: Cytoplasmic tubular aggregates ; Electron microscopy ; Growth hormone cells ; Pituitary adenoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Electron microscopy revealed the presence of cytoplasmic tubular aggregates in the capillary endothelium of a sparsely granulated growth hormone cell adenoma removed surgically from a 25-year-old female patient with acromegaly. To our knowledge, this is the second publication describing these structures in hypophysial growth hormone cell adenomas.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00684545
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Growth hormone-producing pituitary adenoma with giant secretory granules (1979)
    Springer
    Acta neuropathologica 46 (1979), S. 239-241 
    Details
    ISSN: 1432-0533
    Keywords: Acromegaly ; Electron microscopy ; Growth hormone ; Pituitary adenoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Unusually large, oval and pleomorphic secretory granules were noted by electron microscopy in an acidophilic adenoma of the pituitary. The tumor, which was removed by surgery from a 42-year-old woman with elevated blood growth hormone levels and the clinical features of acromegaly, was found to contain growth hormone by the immunoperoxidase technique. This ultrastructural abnormality of secretory granules was not reported so far and was not seen among the 58 cases of growth hormone-producing adenomas investigated in our laboratory. The present case clearly shows that the cytogenesis and cellular composition of pituitary adenomas cannot be determined by solely examining the size and shape of secretory granules.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00690852
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Vinblastine-induced ultrastructural changes in perisinusoidal cells of the rat liver (1975)
    Springer
    Research in experimental medicine 165 (1975), S. 245-249 
    Details
    ISSN: 1433-8580
    Keywords: Vinblastine ; Liver ; Perisinusoidal cell ; Microtubules ; Electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Vinblastine, given intravenously to rats, leads to disappearance of microtubules, formation of paracrystalline inclusions and accumulation of fat droplets in the cytoplasm of the perisinusoidal cells of the liver suggesting that microtubules of the perisinusoidal cells play a role in lipid metabolism.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01971384
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Effect of cycloheximide on the fine structure of corpus luteum in intact and hypophysectomized rats (1973)
    Springer
    Cell & tissue research 146 (1973), S. 223-235 
    Details
    ISSN: 1432-0878
    Keywords: Corpus luteum (Rat) ; Cycloheximide ; Hypophysectomy ; Electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary In rats, one large intravenous dose of cycloheximide leads to extensive development of two types of membrane-formations in the cells of corpora lutea, within two hours. Both the laminated dense bodies (concentric layers of smooth membranes showing high electron density) and the tubular aggregates (tightly packed smooth tubules with diameter smaller than usual) exhibited obvious connections with endoplasmic reticulum membranes. The reorganization of tubular aggregates gave rise to “crystalloids” showing hexagonal symmetry. The crystalloids, being obviously unstable, were transformed into smooth fingerprints (concentric arrays of paired agranular membranes showing the same density as endoplasmic reticulum membranes). Hypophysectomy, performed 24 hours previously, moderated but did not totally abolish the development of membranous configurations. The described effect of cycloheximide is considered to represent cellular injury, probably due to membrane-denaturation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00307348
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    Paper (German National Licenses)
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