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  • Elimination  (1)
  • Herzleistung  (1)
  • Industrial Chemistry  (1)
  • 1
    ISSN: 1432-2013
    Keywords: dv/dt of Ventricular Pressure Curve of the Heart ; dp/dt of Ventricular Pressure Curve ; Performance of the Heart ; Metabolic Alcalosis ; Pressure Load ; Increased Preload ; dv/dt der Ventrikeldruckkurve des Herzens ; dp/dt der Ventrikeldruckkurve ; Herzarbeit ; Herzleistung ; metabolische Alkalose ; Druckarbeit ; Füllungsdruckerhöhung
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Es wurden Untersuchungen am isolierten Katzenherzen mit der Fragestellung durchgeführt, obdp/dt max unddv/dt max der Druckkurve des linken Ventrikels mit Parameters korrelieren, die sich nicht primär aus der Druckkurve ergeben. Besonders interessierten dabei mögliche Beziehungen zu Arbeit und Leistung des linken Ventrikels. Durch metabolische Alkalose (pH 7,8) erhöhte Druckbelastung und Füllungsdruckerhöhung wurden Dynamik und somit physikalisches Resultat der Systole verändert. Ohne Berücksichtigung dieser unterschiedlichen Versuchsbedingungen ergab sich für jeden Versuch eine gesicherte Korrelation zwischendv/dt max und Arbeit bzw. Leistung des linken Ventrikels. Dagegen ließen sich solche Korrelationen zum Schlag-bzw. Herzzeitvolumen und zur Beschleunigungsarbeit nicht nachweisen. Werden die entsprechenden Korrelationen für die genannten Versuchsbedingungen getrennt untersucht, so besteht teilweise eine Beziehung zwischendv/dt max und Schlag-, Herzzeitvolumen bzw. Beschleunigungsarbeit. dp/dt max hängt in ähnlicher Weise von Arbeit und Leistung des linken Ventrikels ab, es ergaben sich jedoch teilweise kleinere Korrelationskoeffizienten. Aus den Ergebnissen läßt sich eine Proportionalität zwischendv/dt max als wesentlichem dynamischen Parameter der Druckarbeit des Ventrikels und dem physikalischen Resultat seiner Systole ableiten.
    Notes: Summary Experiments were performed at isolated cat hearts to examine correlations betweendp/dt max ordv/dt max of the ventricular pressure curve and stroke volume, cardiac index, 1/2 mv2 and performance of the left ventricle. By metabolic alcalosis, pressure load and increased preload the dynamics of ventricular contraction and its physical result were varied. Each heart showed an exact correlation betweendv/dt max and the physical work of the left chamber per systole, respectively performance. Controversely, there could not be found correlations betweendv/dt max and stroke volume, cardiac index and 1/2 mv2. By separate examination of these correlations at metabolic alcalosis, pressure load or increased preload, there exists a particular dependence ofdv/dt max from these parameters. However, the dependence ofdv/dt max from left ventricular work per systole is unchanged. Similar correlations were found betweendp/dt max and the left ventricular work per systole. It is concluded that there exists a proportionality betweendv/dt max as the most important derivation of the ventricular pressure curve and the physical result of ventricular contraction.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 334 (1986), S. 496-500 
    ISSN: 1432-1912
    Keywords: k-Strophanthines ; Ouabain ; Absorption ; Metabolism ; Elimination ; Man
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In 33 healthy male volunteers, given a single oral and intravenous dose of cymarin (k-strophanthin-α), k-strophanthoside (k-strophanthin-γ) and ouabain (g-strophanthin), enteral absorption and renal excretion of these glycosides and their metabolites were investigated by radioimmunoassay and HPLC. Cymarin was absorbed at 47% of the given dose. After intravenous injection 46% and after oral administration 21% of the given dose, i.e. the total amount as detected by radioimmunoassay which consisted of the unchanged glycoside and its metabolites, were excreted by the kidneys mainly as conjugated metabolites. The half-life of elimination, calculated from the total excreted amount was 13 h (i.v.) and 23 h (p.o.), respectively. k-Strophanthoside was absorbed at 16% of the given dose. After i.v.-injection 73% of the given dose was excreted by the kidneys with a half-life of elimination of 99 h. From this total amount about 70% was excreted as the unchanged drug, the remaining 30% as various metabolites. After oral administration 11% of the given dose were excreted with a half-life of elimination of 22 h. 80% of this amount consisted mainly of conjugated k-strophanthoside and conjugated metabolites as k-strophanthin-β, cymarin, k-strophanthidin, cymarol and k-strophanthidol. Only 6% was excreted as the unchanged drug. Ouabain was absorbed after oral administration to a minimum of 1.4%. Given intravenously a total renal excretion of 33% of the given dose with a half-life of elimination of 23 h was measured. Of this 80% was unchanged ouabain. The remaining 20% seemed to be conjugated metabolites which could not be exactly identified.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Weinheim : Wiley-Blackwell
    Chemie Ingenieur Technik - CIT 69 (1997), S. 1257-1258 
    ISSN: 0009-286X
    Keywords: Chemistry ; Industrial Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
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