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  • 1
    Electronic Resource
    Electronic Resource
    Embryonales Carcinom der Epiphysenregion (1970)
    Springer
    Acta neuropathologica 15 (1970), S. 176-182 
    Details
    ISSN: 1432-0533
    Keywords: Embryonal Carcinoma ; Germinoma ; Pineal Region ; Germinal Neoplasms, Cerebral and Extracerebral
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Bei einem 13 jährigen Knaben mit 4 monatiger Krankheitsdauer fand sich ein großer, von der Pinealisregion ausgehender, maligner Tumor, der histologisch als embryonales Carcinom mit einfachen epithelialen (adenocarcinomatösen und acinären) Differenzierungsformen, Endodermalsinus und germinom-(seminom-)artigen Anteilen imponierte. Diese Beobachtung bestätigt 1. die engen strukturellen Beziehungen zwischen embryonalem Carcinom, malignem Teratom und Germinom (Seminom) sowie 2. die Annahme einer morphologischen und histogenetischen Verwandtschaft der Stammzellgeschwülste des ZNS und der Gonaden. Für beide Tumorgruppen wird die gleiche Nomenklatur vorgeschlagen.
    Notes: Summary In a 13-year old boy with 4 months' illness a large tumor of the pineal region was observed, the histological structure of which was that of an embryonal carcinoma with early epithelial (adenocarcinomatous and acinar) differentiation and endodermal sinuses associated with germinoma-(seminoma-) like areas. The present observation indicates 1. the close structural relationship between embryonal carcinoma, malignant teratoma and germinoma (seminoma), and 2. supports the concept of structural and histogenetic analogy between the germinal tumors of the brain and those of the gonades. It is proposed that the same basic nomenclature be adopted for both groups of neoplasms.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00685269
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  • 2
    Electronic Resource
    Electronic Resource
    Primary intracranial germ cell tumours (1973)
    Springer
    Acta neuropathologica 25 (1973), S. 291-306 
    Details
    ISSN: 1432-0533
    Keywords: Germ Cell Tumours ; Dysgerminomas ; Germinoma ; Embryonal Carcinoma ; Endodermal Sinus Tumour ; Teratoma ; “Mixed” Neoplasms
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A histological study has been made of a retrospective series of 17 primary intracranial germ cell tumours found in a collection of 3550 intracranial neoplasms (incidence of 0.48%). All, except for two differentiated teratomas (one extracerebral in a neonate and another in the lateral ventricle), were situated in the midline in persons aged 5 to 37 years (13 males, 4 females). 12 tumours were located in or originated from the (para)pineal region, two of them also invaded the hypothalamus, while three germinomas occupied the retrochiasmal (supra/intrasellar) region without pineal involvement. There were 11 rather pure tumours (7 germinomas, 4 teratomas of various differentiation) and six “mixed” neoplasms (2 germinomas with teratoid areas, 3 embryonal carcinomas containing elements of endodermal sinus tumour, choriocarcinoma and germinoma, and one teratocarcinoma with endodermal sinuses). Only one case showed prominent features of endodermal sinus tumour, but characteristic elements of this type were present in four other “mixed” tumours. All germinomas and germinomatous parts of mixed neoplasms showed an inflammatory reaction of varying intensity, in 6 cases associated with multinucleated giant cells, which may be related to the prognosis of these tumours (one patient with hypothalamic germinoma is alive 6 years after radiotherapy). The close structural similarities between the various types of intracranial and gonadal dysgerminomas and their frequent combination within the same tumour support the concept of a common histogenesis of germ cell tumours regardless of their site of origin. Difficulties of classification may arise from the rather frequent occurrence of “mixed” germ cell neoplasms.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00691757
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    Paper (German National Licenses)
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