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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Journal of neurology 228 (1982), S. 277-281 
    ISSN: 1432-1459
    Keywords: Facial palsy ; Polymyositis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Wir berichten über einen Fall einer entzündlichen Myopathie mit fazio-pharyngo-proximaler Beteiligung. Fazialisparese als wichtigstes Zeichen ist ungewöhnlich im Rahmen einer Polymyositis. Die besondere Verteilung der Muskelschwäche, welche unsere Patientin aufwies, ist eine klinische Variante, bei welcher immer nach einem entzündlichen Prozeß gesucht werden muß, da eine Steroidtherapie hier mit Erfolg angewendet werden kann.
    Notes: Summary A case of imflammatory myopathy with faciopharyngoproximal distribution is reported. It is very unusual for facial weakness to be a major feature in polymyositis, but when other muscles are involved the clinician should be stimulated to look for an inflammatory myopathy. Marked improvement may be achieved as a result of corticosteroid therapy.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Journal of neurology 236 (1989), S. 246-248 
    ISSN: 1432-1459
    Keywords: Muscular diseases, chemically induced ; Emetine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A young anorexic woman is described with a history of progressive muscle weakness following chronic ingestion of syrup of ipecac that was used in an attempt at weight control. Electrocardiogram (ECG) showed T-wave inversion in all leads and prolongation of the Q-T interval. Electromyography was abnormal. Muscle biopsy revealed a randomized, generalized, predominantly type-2 fibre atrophy and structural alterations in oxidative enzyme stains, such as targetoid and motheaten fibres. A few necrotic cells were actively phagocytosed. Electron microscopy revealed severe sarcomeric abnormalities with Z-line streaming, myofibrillar disorganization and increased lysosomal activity. After discontinuation of ipecac syrup, the patient noted a gradual improvement in her condition. The ECG became normal. Emetine and related drug-induced myopathies are uncommon but are of experimental interest because of their effects on mitochondria and the light they shed on autophagic mechanisms in muscle.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
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