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  • 1
    Electronic Resource
    Electronic Resource
    Increased populations of endocrine cells in Crohn's ileitis (1987)
    Springer
    Virchows Archiv 410 (1987), S. 391-396 
    Details
    ISSN: 1432-2307
    Keywords: Crohn's disease ; Immunocytochemistry ; Endocrine cells
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Hyperplasia of nerves has been described previously in Crohn's disease. To determine whether similar alteration of the enteric endocrine system occurs, endocrine cells of the ileal epithelium were quantified in typical cases of the disease. In the ileum from patients with Crohn's disease, there was an increase in the endocrine cell population, as visualised by immunostaining of chromogranin. Quantification of endocrine cell numbers showed significant increases in both macroscopically uninvolved (i.e. histologically normal) (35.0±3.8, cells per unit length of muscularis mucosae mean ±SEM,P〈0.05) and involved (44.5±5.5,P〈0.01) Crohn's disease samples, compared with normal controls (23.7±3.4). Although individual types of endocrine cell showed slight increases in Crohn's samples, only the enterochromaffin cells in abnormal bowel showed a significantly greater population (normal controls 10.5±2.3; involved Crohn's 21.3±4.4,P〈0.05).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00712758
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Endocrine differentiation in inflamed urinary bladder epithelium with metaplastic changes (1988)
    Springer
    Virchows Archiv 412 (1988), S. 267-272 
    Details
    ISSN: 1432-2307
    Keywords: Cystitis ; Metaplasia ; Endocrine cells ; Urinary bladder
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Several types of metaplasia can occur in human bladder epithelium under certain pathological conditions. We investigated 65 cases of cystitis, associated with different types of metaplasia, for the presence of endocrine cells, using histochemical and immunocytochemical methods. Tissues were obtained at cystoscopy and were routinely fixed in 10% buffered formalin. Endocrine cells were demonstrated, between the epithelial cells, in 40 out of 50 cases of cystitis glandularis or cystica. These cells were positive by the Grimelius' silver impregnation technique and were immunoreactive for protein gene product (PGP 9.5), a new general neuroendocrine marker, chromogranin and serotonin. No endocrine cells were detected in any of the specimens of normal epithelium nor those showing squamous metaplasia. Eighteen of these cases showed prominent nerve bundles in the sub-epithelial tissue, as revealed by PGP immunoreactivity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00737151
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    CGRP-immunoreactive endocrine cell proliferation in normal and hypoxic rat lung studied by immunocytochemical detection of incorporation of 5′-bromodeoxyuridine (1992)
    Springer
    Cell & tissue research 268 (1992), S. 9-15 
    Details
    ISSN: 1432-0878
    Keywords: Lung ; Endocrine cells ; Calcitonin generalated peptide ; Bromodeoxyuridine ; Differentiation ; Proliferation ; Hypoxia ; Rat (Wistar)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary We have tested the suggestion that the reported increase, in hypoxic rats, in the number of lung endocrine cells immunoreactive for the regulatory peptide CGRP is caused by an accumulation of peptide within the cells which renders them more detectable, rather than by a real increase in proliferation. The incorporation of continuously infused 5′-bromodeoxyuridine (BrdU) into nuclei of CGRP-containing cells was studied by immunohistochemistry in the airway and respiratory epithelium of rats kept in a hypoxic (10% O2), normobaric conditions for 7 days and in normoxic, normobaric controls. Some CGRP-immunoreactive cells could also be labelled for BrdU. However, the ratio of the number of cells labelled with both CGRP and BrdU to the number of cells labelled with CGRP alone did not differ significantly between hypoxic and normoxic rats (7.1±0.7 and 6.1±1.2, respectively; mean±SEM; P=0.49). These data strongly suggest that CGRP-containing endocrine cells or their precursors do proliferate in adult rat lung, but that the proliferation is not increased significantly in hypoxia.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00338049
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Regulatory peptides in the gastrointestinal tract of Alligator mississipiensis (1983)
    Springer
    Cell & tissue research 231 (1983), S. 439-449 
    Details
    ISSN: 1432-0878
    Keywords: Evolution ; Regulatory peptides ; Gut ; Endocrine cells ; Peripheral innervation ; Alligator mississipiensis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The gastrointestinal tract of the alligator Alligator mississipiensis has been investigated for the presence of immunoreactivity to fourteen regulatory peptides all known to occur in the mammalian gut system. Mucosal endocrine cells reacting specifically with the antisera to neurotensin, C-terminal gastrin, somatostatin, bombesin, secretin, pancreatic glucagon and enteroglucagon were detectable, the distribution of these cells being, in general, similar to the mammalian pattern. Peripheral nerve cell bodies and nerve fibres were detected with the antisera to vasoactive intestinal polypeptide, substance P, bombesin and somatostatin again with a distribution similar to that seen in mammals. No immunoreactivity was observed with the available antisera to glicentin, motilin, gastric inhibitory polypeptide, gastrin 34, cholecystokinin 9–20 and met-enkephalin.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00222193
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Nitric oxide (NO) synthase immunoreactivity in the starfish Marthasterias glacialis (1994)
    Springer
    Cell & tissue research 275 (1994), S. 599-603 
    Details
    ISSN: 1432-0878
    Keywords: Nitric oxide synthase ; Nervous system ; Gut ; Endocrine cells ; Immunocytochemistry ; Marthasterias glacialis (Echinodermata)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The neuroendocrine system of the starfish Marthasterias glacialis was investigated immunocytochemically using antisera specific for rat neuronal, bovine aortic endothelial, and mouse macrophage, nitric oxide (NO) synthases. Immunoreactivity was detected only with the antibodies specific for the neural enzyme, in the ectoneural and hyponeural tissues of the radial nerve cords and in the basiepithelial plexus and endocrine cells of the digestive tract. The pyloric stomach showed more immunoreactive structures than the other digestive organs, with the rectal caeca showing the least activity. Immunoreactive endocrine cells were located in the cardiac and pyloric stomachs and in the pyloric caeca. Co-localization of the enzyme immunoreactivity, and the staining for NADPH-diaphorase, demonstrate the presence of NO synthase in echinoderms. These results provide further evidence that NO is a neuronal messenger of early phylogenetic origin which has been conserved throughout evolution.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00318828
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    Paper (German National Licenses)
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