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  • 1
    Electronic Resource
    Electronic Resource
    Enteroglucagon and peptide Y-Y response after construction of a pelvic reservoir in humans (1990)
    Springer
    Diseases of the colon & rectum 33 (1990), S. 966-970 
    Details
    ISSN: 1530-0358
    Keywords: Gut peptides ; Ileal reservoir ; Pelvic pouch
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The results of an investigation on plasma levels of gastrointestinal hormones in patients after the construction of a pelvic reservoir are reported. Enteroglucagon (EG) and peptide tyrosine-tyrosine (PYY), two hormones believed to play a relevant role in the adaptive response of bowel resection, were investigated using a specific radioimmunoassay in basal conditions and after a standard meal. Pouch patients showed a statistically significant increase in basal levels of both enteroglucagon and PYY compared with control subjects ( P 〈0.02 and P 〈0.001, respectively). The response of enteroglucagon to food ingestion, evaluated by means of the total integrated response, was similar in patients and controls. Conversely, the response of PYY was significantly increased in pouch patients compared with control cases ( P 〈0.02). Results of this investigation suggest that gut hormones may be involved in mediating the adaptive response of the intestine to pouch construction. Changes of gut peptides may explain, at least in part, the functional results observed after pouch construction.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02139107
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  • 2
    Electronic Resource
    Electronic Resource
    Immunocytochemical study of endocrine cells in pelvic ileal reservoirs (1990)
    Springer
    Diseases of the colon & rectum 33 (1990), S. 703-706 
    Details
    ISSN: 1530-0358
    Keywords: Ileal reservoir ; Pelvic pouch ; Peptides gut endocrine cell
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The distribution and morphology of intestinal endocrine cells was investigated in the mucosa of pelvic ileal reservoirs using immunocytochemical methods. Endoscopic biopsies were obtained from 15 patients after the construction of a modified J-pouch. The mucosa of the reservoir showed a variable degree of colonic metaplasia in all cases. No relevant quantitative variations of gut endocrine cells were detected, as revealed by immunostaining for the general marker, chromogranin, compared with normal ileal mucosa. Immunostaining for different peptide-containing cells resulted in normal number and morphology of serotonin, enteroglucagon, peptide tyrosine-tyrosine, and somatostatin-containing cells. Neurotensin cells were less numerous than in normal mucosa. The role played by gastrointestinal hormones in the adaptive response of the intestine to pouch construction is, presently, unclear. Further studies involving measurements of fasting and meal-stimulated levels of gut hormones in pouch patients might clarify this aspect.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02150749
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  • 3
    Electronic Resource
    Electronic Resource
    Combined biofeedback, physiotherapy and electrostimulation for fecal incontinence (2000)
    Springer
    Techniques in coloproctology 4 (2000), S. 157-161 
    Details
    ISSN: 1128-045X
    Keywords: Key words Fecal incontinence ; Biofeedback ; Physiotherapy ; Electrostimulation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Different outcomes are reported in the literature following pelvic floor rehabilitation for fecal incontinence, possibly due to the type of procedure employed, whether biofeedback or physiotherapy or electrostimulation. The aim of the present study is to analyze the results achieved in a group of patients treated with a combination of the three procedures. Thirty-two patients (24 females) affected by fecal incontinence underwent a course of combined rehabilitation (CR); 23 of them had anal surgery prior to CR, for rectal mucosal prolapse and hemorrhoids in most cases. Eighteen had anal manometry before and after CR. Sixteen underwent anal ultrasound prior to treatment. Patients were taught perineal exercises, biofeedback was either sensory or electromyographic, and electrostimulation was performed with a 10–20 MHz endoanal probe. Twenty-seven patients were available for follow-up. The mean incontinence score improved from 4.0±0.8 to 2.1±1.7 (mean±sd) (p〈0.001); 19 patients (70%) were satisfied after CR, and 11 (44%) were fully continent. Post-treatment manometry showed an increased amplitude of squeeze pressure in 50% of the cases, whereas 61% had an increase in duration, but only 27% of them had a positive clinical outcome. Rectal evacuation thresholds improved in 55% of the cases and 86% of them had a corresponding positive clinical outcome. At ultrasound, 6 patients showed intact anal sphincters and had a positive outcome following CR. Pelvic floor rehabilitation seems to be effective for the management of fecal incontinence when carried out combining different types of procedures. No significant correlation was found between manometric and clinical response to the treatment. An increase of rectal sensation may be responsible for the clinical improvement.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s101510070008
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  • 4
    Electronic Resource
    Electronic Resource
    Diagnosis and treatment of haemorrhoids in the elderly: results from 291 patients (1999)
    Springer
    Techniques in coloproctology 3 (1999), S. 127-130 
    Details
    ISSN: 1128-045X
    Keywords: Key words Haemorrhoids ; Elderly
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Haemorrhoids are believed to be rare in elderly patients, occurring mainly in young and middle-aged subjects. Symptoms of haemorrhoids in elderly patients, in addition, require a precise differential diagnosis in order to rule out neoplasia. In this paper we report our experience in dealing with haemorrhoidal disease in 291 patients older than 65 years. Symptoms of presentation were those commonly reported by younger patients. Accurate clinical examination, proctoscopy and flexible sigmoidoscopy allowed reaching a differential diagnosis in the majority of patients. Extensive colorectal diagnostic screening was required in 28.5% of patients due to the clinical presentation. Treatment was conservative in most cases, with 57.2% of the patients treated medically and 36.7% undergoing rubber band ligation (RBL). In this group of patients no complications occurred although several risk factors were present (e.g. anticoagulant medications, diabetes, cardiovascular diseases). A further 13% of the patients underwent surgery with no complications or mortality. Haemorrhoids in elderly patients occur with features similar to those of other ages and ambulatory treatment can be performed. In particular, RBL can be performed safely even in those patients presenting with associated illness.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s101510050031
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  • 5
    Electronic Resource
    Electronic Resource
    Acute colonic dilatation associated with a painful anal fissure (2000)
    Springer
    Techniques in coloproctology 4 (2000), S. 169-171 
    Details
    ISSN: 1128-045X
    Keywords: Key words Anal fissure ; Acute colonic dilatation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We report the case of an elderly woman who developed acute colon dilatation as a consequence of a painful fissure of the anus with severe hypertonia. After having excluded mechanical aetiology, a lateral internal sphincterotomy was performed under local anaesthesia. The procedure cured the anal pain and, by facilitating normal bowel function, allowed resolution of abdominal symptoms. The aetiology of acute colonic dilatation in this patient may be related to the painful anal fissure and hypertonia. In the elderly, the presence of simple anal diseases may predispose to the occurrence of life-threatening complications, such as acute colonic dilatation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s101510070010
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  • 6
    Electronic Resource
    Electronic Resource
    Derivatives of pre-pro-hormone molecules in neuroendocrine tumours
    Amsterdam : Elsevier
    Regulatory Peptides 10 (1985), S. S16 
    Details
    ISSN: 0167-0115
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0167-0115(85)90308-8
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  • 7
    Electronic Resource
    Electronic Resource
    Pre-pro-VIP derivatives in the enteric innervation
    Amsterdam : Elsevier
    Regulatory Peptides 10 (1985), S. S25 
    Details
    ISSN: 0167-0115
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0167-0115(85)90327-1
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  • 8
    Electronic Resource
    Electronic Resource
    Increased populations of endocrine cells in Crohn's ileitis (1987)
    Springer
    Virchows Archiv 410 (1987), S. 391-396 
    Details
    ISSN: 1432-2307
    Keywords: Crohn's disease ; Immunocytochemistry ; Endocrine cells
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Hyperplasia of nerves has been described previously in Crohn's disease. To determine whether similar alteration of the enteric endocrine system occurs, endocrine cells of the ileal epithelium were quantified in typical cases of the disease. In the ileum from patients with Crohn's disease, there was an increase in the endocrine cell population, as visualised by immunostaining of chromogranin. Quantification of endocrine cell numbers showed significant increases in both macroscopically uninvolved (i.e. histologically normal) (35.0±3.8, cells per unit length of muscularis mucosae mean ±SEM,P〈0.05) and involved (44.5±5.5,P〈0.01) Crohn's disease samples, compared with normal controls (23.7±3.4). Although individual types of endocrine cell showed slight increases in Crohn's samples, only the enterochromaffin cells in abnormal bowel showed a significantly greater population (normal controls 10.5±2.3; involved Crohn's 21.3±4.4,P〈0.05).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00712758
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  • 9
    Electronic Resource
    Electronic Resource
    Immunocytochemical study of the hepatic innervation in the rat after partial hepatectomy (1987)
    Springer
    Journal of molecular histology 19 (1987), S. 327-332 
    Details
    ISSN: 1573-6865
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The autonomic nervous system in rats has been assessed by means of indirect immunofluorescence using monospecific antibodies to neuron-specific enolase, neurofilaments, glial fibrillary acidic protein and S-100 protein (10 days after partial (70%) hepatectomy). Different groups of rats were studied: group A: 70% resection and normal dual blood supply (n=5); group B: 70% resection with only portal blood to the liver remnant (n=5); group C: 70% resection with only arterial blood to the liver remnant (n=5); group D: sham operated controls (n=5). All rats of groups A and D showed normal liver/body weight ratios after 10 days in contrast to groups B and C where liver weights were 50–60% of the preresection weight. In group A the regeneration process was histologically normal and associated with a remarkable increase of autonomic innervation patterns in the portal triad. In contrast, livers of animals in groups B and C showed under the light microscope features of hepatocyte degeneration associated with a decreased autonomic innervation compared to the controls. The changes are identical in groups B and C, and are therefore irrespective of the type of blood deprivation (arterial or portal). These results support the importance of dual blood supply for an optimal regenerative response in liver remnants after liver resection. We suggest that the autonomic nerve supply of the portal triad plays at least an important permissive role in liver regeneration.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01680448
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