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  • Endocrine ophthalmopathy  (1)
  • Key words: Metalloproteinases — Arthritis — TNFα  (1)
  • Langmuir model  (1)
  • Quality  (1)
  • 1
    ISSN: 1432-1440
    Schlagwort(e): Graves' disease ; HLA-DRB3 alleles ; Endocrine ophthalmopathy
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Graves' disease (GD) is a human leukocyte antigen (HLA) linked organ-specific autoimmune disease. In German GD patients the disease is associated with HLA specificities of the HLA-DRw52 family (HLA-DR3, -DR5, and DR6; HLA-DRB3 positive HLA haplotypes). Recently, a strong association with a HLA-DRB3 restriction fragment length polymorphism gene has been described. To study HLA-DRB3 alleles and their association with the disease, a large cohort of controls (n = 3724) and GD patients (n = 304) was analyzed. HLA-DR allelic combinations revealed an increase in HLA-DR3/DR5 heterozygous patients (relative risk 2.9; P〈0.001). HLA-DRB3 alleles, as defined by DNA typing in HLA-DR matched groups revealed a significant increase in DRB3*0101 homozygosity (relative risk 17.5; P〈 0.001) in HLA-DR3 homozygous patients. In GD patients with ophthalmopathy (grade II or higher, according to Werner) DRB3*0101/*0202 heterozygosity revealed an increased relative risk of 5.5 (P〈0.001). Non-HLA-DR3 homozygous, DRB3*0101/*0202 heterozygous patients were at the highest risk for endocrine ophthalmopathy (relative risk 10; P〈0.001). Our data, based on DNA typing methods of HLA-D genes, provide evidence that the susceptibility is strongly associated with HLA-DRB3 genes.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    Amsterdam : Elsevier
    Journal of Analytical and Applied Pyrolysis 17 (1990), S. 189-199 
    ISSN: 0165-2370
    Schlagwort(e): Coke formation ; Langmuir model ; hydrocarbons ; mathematical model ; pyrolysis.
    Quelle: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Thema: Chemie und Pharmazie
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 3
    ISSN: 1420-908X
    Schlagwort(e): Key words: Metalloproteinases — Arthritis — TNFα
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract. Objective and Design: The effects of two hydroxamate inhibitors of metalloproteinase and tumor necrosis factor α (TNFα) processing on endotoxin-induced plasma TNFα and arthritic lesions in adjuvant-induced arthritic (AA) rats were determined.¶Material and Treatment: BB-1101 and BB-1433 were administered orally twice daily to AA Lewis rats with an established disease (days 13 to 22). AA rats (day 16) or normal rats were injected with bacterial endotoxin and plasma levels of TNFα were also determined.¶Methods: Hindpaw swelling was measured plethysmographically. Bone degradation was determined by radiography and bone mineral densitometry. TNFα was quantified using a sandwich ELISA.¶Results: The hydroxamic-acid pseudopeptides inhibited plasma TNFα levels in vivo and significantly reduced swelling and bone degradation of the tibiotarsal joints of AA rats in the range of 10–50 mg/kg given orally ( p 〈 0.01 by Student's t-test).¶Conclusions: Thus, these novel compounds offer a new disease-modifying therapy for arthritis and the results also suggest that inhibition of TNFα production may contribute, at least in part, to their anti-arthritic activity.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 4
    ISSN: 1432-1238
    Schlagwort(e): Key words Mechanical ventilation ; Endotracheal intubation ; Unplanned ; extubation ; Self-extubation ; Intensive care unit ; Quality ; improvement
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Objective: To evaluate the effectiveness of a continuous quality improvement (CQI) program in reducing the incidence of unplanned endotracheal extubation. Design: Prospective study over a 9-month period. Setting: Adult intensive care units (ICUs including coronary care unit, medical ICU, surgical ICU, and cardiovascular surgical ICU) in a university-affiliated medical center. Patients: 831 consecutive mechanically ventilated patients. Interventions: CQI program focusing on standardization of procedures, improvement of communication, and identification and management of high-risk patients. Measurements and results: With the implementation of this CQI program, the overall incidence density of unplanned extubation (defined as number of new unplanned extubations per mechanical ventilation patient-days) significantly decreased from 2.6% in the first trimester to 1.5% in the second trimester and 1.2% in the third trimester (p=0.01). This reduction was essentially the result of a decrease in unplanned extubation in orally intubated patients (incidence density 4.6, 1.7 and 1.0% for three trimesters, respectively; p〈0.0001). Unplanned extubation in nasally intubated patients remained largely unaffected (1.2, 1.4, and 1.4% for three trimesters, respectively; p=0.92). Conclusions: The implementation of a concerted CQI program is effective in reducing the overall incidence of unplanned endotracheal extubation.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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