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  • 1
    ISSN: 1432-2013
    Keywords: Nucleoside transport ; Nitrobenzylthioinosine (NBMPR) ; Microvillous and basal membrane vesicles ; Placenta (human)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Polyclonal antibodies raised against the human erythrocyte nucleoside transporter were used to investigate the distribution of the nucleoside transporters in the placenta. Immunoblots of brush-border membranes isolated from the human syncytiotrophoblast revealed a cross-reactive species that co-migrated with the erythrocyte nucleoside transporter as a broad band of apparent M r 55,000. In contrast, no labelling was detected in basal membranes containing a similar number of equilibrative nucleoside transporters as assessed by nitrobenzylthioinosine (NBMPR)-binding. The absence of cross-reactive epitopes in basal membranes and their presence in brush-border membranes was confirmed by confocal immunofluorescence microscopy. These results suggest that at least two isoforms of the NBMPR-sensitive nucleoside transporter are present in the human placenta. The lumenal surfaces of fetal capillaries, small placental vessels and umbilical vein were also strongly labelled by the antibody, a finding that suggests that the high fetal-placental adenosine uptake previously reported is due to endothelial transporters.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Chichester : Wiley-Blackwell
    International Journal for Numerical Methods in Fluids 20 (1995), S. 1179-1197 
    ISSN: 0271-2091
    Keywords: adaptive grids ; equidistribution ; compressible viscous aerodynamics ; CFD modelling ; Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: A technique is described for the adaptation of a structured control volume mesh during the iterative solution process of the Navier-Stokes equations. The scalar equidistribution method is adopted, in conjunction with a Laplace-like grid solver to make a curvilinear body-fitted grid sensitive to local flow gradients. Hence, whilst the total number of grid nodes remains constant during a computation, their relative position is continuously adjusted to promote clustering of cells in regions where gradients are high. The focus of this work is in compressible aerodynamics, where such clustering would be desirable in regions containing shocks but also in boundary layers. The technique is three-dimensional and operates in a series of user-defined grid subdomains or patches. These patches act as reference frames within which grid activity takes place. Bi-cubic splines are extensively used to define the aerodynamic surfaces forming the calculation boundaries and to ensure that grid movement does not compromise surface integrity. The technique is applied to aerofoils, wing surfaces, transonic ducts and nozzles and a supersonic wedge cascade. Significant sharpening of both normal and oblique shock discontinuities is demonstrated over static grid simulations and with fewer overall grid nodes. The technique is successful in both inviscid and viscous (turbulent) simulations.
    Additional Material: 16 Ill.
    Type of Medium: Electronic Resource
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