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  • 1
    ISSN: 0942-0940
    Keywords: Cerebral vasospasm ; nicardipine ; papaverine ; subarachnoid haemorrhage
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The clinical effect of combination therapy with high doses of intravenous nicardipine and intra-arterial infusion of papaverine on symptomatic vasospasm after subarachnoid haemorrhage (SAH) was analysed retrospectively. In 66 of 122 patients who underwent early aneurysm surgery between 1990 and 1993, the intracranial haemodynamics were documented by transcranial Doppler (TCD) ultrasonography. 33 of these 66 patients received high dose nicar-dipine intravenously (Group I); the other 33 patients were not treated with calcium antagonists (Group II). Symptomatic vasospasm occurred in 6 Group I patients (18%) and in 13 (39%) in Group II patients. All 19 symptomatic patients received an intra-arterial infusion of papaverine; 15 patients (79%) responded well to this therapy and the symptoms were reversed quickly. Although the mean flow velocity (MFV) was not different between the two groups, it was reduced significantly after papverine infusion. Our retrospective analysis suggests that symptomatic vasospasm can be treated effectively with the combination of intravenous high dose nicardipine and intra-arterial infusion of papaverine, and that the correct timing of the infusions is crucial.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 0942-0940
    Keywords: Cerebral vasospasm ; concentration ; papaverine ; subarachnoid haemorrhage
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We evaluated the effect of intra-arterially infused papaverine solutions of various concentrations on cerebral vasospasm following subarachnoid haemorrhage. A total of 90 vascular territories in 46 patients with symptomatic cerebral vasospasm after subarachnoid haemorrhage were treated with intra-arterial infusions of papaverine. In all patients, papaverine was infused at the top of the internal carotid artery (ICA). Of the 90 vascular territories, 30 vascular territories in 14 patients were treated with an infusion of 0.1–0.2% (weight/volume) papaverine (Group 1), 30 vascular territories in 16 patients were treated with a 0.4% (w/v) papaverine infusion (Group 2), and 30 vascular territories in 16 patients were treated with an infusion of 0.8–2.0% (w/v) papaverine (Group 3). Among the three groups, we compared the vasodilatory effects of papaverine by assessing the angiographical and clinical improvements following the treatment. When 0.4% (w/v) papaverine was infused, 24 vascular territories (80%) were successfully dilated and 7 patients (44%) showed a marked reversal of neurological deficits due to vasospasm. Therefore, 80 mg/20 ml (0.4% (w/v)) papaverine infused over a 10-minute period proved to be a beneficial concentration. Transient focal neurological deficits due to the infusion of papaverine occurred in 1 Group 1 patient (7%), 1 Group 2 patient (6%), and 7 Group 3 patients (44%). Highly concentrated papaverine had a higher risk of temporary deterioration. In conclusion, the papaverine concentration of 0.4% (w/v) infused at the top of the ICA was a safe and adequate concentration for treating cerebral vasospasm.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 29 (1990), S. 1539-1549 
    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: This paper is concerned with the improvement of the efficiency and accuracy of the usual numerical integration procedures for the finite element method. A modified numerical integration scheme based on both the symbolic manipulation system and the numerical integration formula is proposed. Its efficiency for the integration of complicated rational or irrational expressions is demonstrated through several numerical examples. To verify its effectiveness in the calculation of the finite element stiffness matrix, a simple numerical example is also presented.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 39 (1996), S. 3953-3968 
    ISSN: 0029-5981
    Keywords: inverse problem ; neural networks ; regularization ; data transformation ; structure identification ; vibration analysis ; Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: The present authors have been developing an inverse analysis approach using the multilayer neural network and the computational mechanics. This approach basically consists of the following three subprocesses. First, parametrically varying model parameters of a system, their corresponding responses of the system are calculated through computational mechanics simulations such as the finite element analyses, each of which is an ordinary direct analysis. Each data pair of model parameters vs. system responses is called training pattern. Second, a neural network is iteratively trained using a number of training patterns. Here the system responses are given to the input units of the network, while the model parameters to be identified are shown to the network as teacher data. Finally, some system responses measured are given to the well-trained network, which immediately outputs appropriate model parameters even for untrained patterns. This is an inverse analysis. This paper proposes a new regularization method suitable for the inverse analysis approach mentioned above. This method named the Generalized-Space-Lattice (GSL) transformation transforms original input and/or output data points of all training patterns onto uniformly spaced lattice points over a multi-dimensional space. The topological relationships among all the data points are maintained through this transformation. The neural network is then trained using the GSL-transformed training patterns. Since this method significantly remedies localization of training patterns caused due to strong nonlinearity of problem, the neural network can learn the training patterns efficiently as well as accurately. Fundamental performances of the present inverse analysis approach combined with the GSL transformation are examined in detail through the identification of a vibrating non-uniform beam in Young's modulus based on the observation of its multiple eigenfrequencies and eigenmodes.
    Additional Material: 13 Ill.
    Type of Medium: Electronic Resource
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