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  • Engineering General  (2)
  • Free radicals  (1)
  • Gastric cancer  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Free Radical Biology and Medicine 7 (1989), S. 499-505 
    ISSN: 0891-5849
    Keywords: Fenton reaction ; Free radicals ; H"2O"2 ; Lens crystallins ; Oxidation ; Protein modification ; hydroxyl radical
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-2307
    Keywords: Gastric cancer ; p53 tumour-suppressor gene ; Mutation spectrum ; Dietary mutagens ; Immunohistochemistry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The p53 tumour-suppressor gene plays an important role in gastric carcinogenesis. In an analysis of the spectrum of mutations of the p53 gene seen in 56 primary gastric carcinomas of various types and grades of differentiation, the entire coding sequence (exons 2–11) of the p53 gene was screened by single-strand conformation polymorphism analysis and direct genomic sequencing of polymerase chain reaction products. Intragenic restriction site polymorphisms and the probe YNZ22 were used for the detection of loss of heterozygosity (LOH) of the p53 gene locus on chromosome 17p. p53 overexpression was studied with the anti-p53 antibody CM-1. A total of 21 somatic alterations of the p53 gene were found. Twenty were base-pair substitutions, and one was an eight base-pair deletion. Six tumours with p53 mutations revealed LOH. Abnormalities in p53 expression were found in 17 tumour samples, of which 16 had gene mutations. The spectrum of mutations observed was consistent with the predicted spectrum for dietary mutagens associated with the metabolism of nitrogenous compounds, resulting in deamination of nucleic acids. Our findings suggest that p53 could be a primary target for mutations associated with dietary carcinogens in gastric carcinogenesis.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 36 (1993), S. 2643-2659 
    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: The paper presented here reviews the numerical techniques used currently to calculate the singular integrals and nearly singular integrals in the boundary element analysis. Some incorrect algorithms published before are discussed and a new numerical technique to calculate the nearly singular integral is developed. The numerical results show a significant improvement in both accuracy and efficiency compared to the traditional adaptive Gaussian quadrature and subdivision techniques.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 37 (1994), S. 2041-2072 
    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: The work reported herein develops a generalized traction-BIE formulation which involves only weakly singular integrals (in the three-dimensional problem) or totally regular integrals (in the two-dimensional problem). The first step deals with the terms in the Somigliana displacement identity, and then the derivatives of these terms. The only conditions required for the existence of the traction-BIE and the related Somigliana stress identity are weak continuity of the in-plane derivatives of the surface displacements and of the surface tractions. It is shown that the Cauchy Principal Value (CPV) interpretations so commonly used in BIE developments are unnecessary. The formulation is established not only at a smooth boundary point, but also at a corner point. The extension of the non-singular formulation to discontinuous boundary tractions and tangential derivatives of the boundary displacements applicable to a generalized problem statement as well as the usual BEM implementations is also shown. In the demonstrated formulation, the source points are located directly at the boundary nodes and non-conformal elements are not needed.
    Additional Material: 17 Ill.
    Type of Medium: Electronic Resource
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