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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Cellular and molecular life sciences 45 (1989), S. 444-452 
    ISSN: 1420-9071
    Keywords: Ethanol ; monoamines ; ventral tegmental accumbens-hypothalamic axis ; opioid peptides ; pineal gland
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Uncontrollable alcohol ingestive behavior has been linked to deficits of central neurotransmission. The pineal gland plays an important role in modulating ethanol intake in numerous animal species. The opioidergic (i.e. β-endorphin, enkephalin, and dynorphin) system is involved in both the actions of alcohol and opiates, as well as craving and/or genetic predisposition towards abuse of these two agents. Furthermore, there is significant evidence to link ingestive behaviors with the ventral tegmental accumbens-hypothalamic axis, whereby the biogenic amines dopamine and serotonin are reciprocally involved. Evidence is presented which implicates the striatum and the hypothalamus as possible specific loci for regional differences between alcohol-preferring and alcohol-nonpreferring mice. We believe that photoperiod-induced alcohol ingestive behavior may involve alterations in both pineal and hypothalamic opioid peptides.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Cellular and molecular life sciences 41 (1985), S. 932-933 
    ISSN: 1420-9071
    Keywords: Methionine-enkephalin ; cerebral blood-flow ; putative-neurotransmitter ; swine ; brain regions ; neuromodulator
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary In swine, cerebral blood flow was documented by a left ventricular injection of radiolabeled 15-micron spheres. Utilizing this procedure, the effect of the putative neurotransmitter methionine-enkephalin on regional cerebral blood flow was systemically evaluated. Our results revealed that a peripheral infusion of methionine enkephalin into miniature swine significantly increased cerebral blood flow in the basal ganglia, cerebellum, pons, inferior parietal cortex, superior parietal cortex and frontal cortex. Non-significant increases were observed in the hippocampus, occipital cortex and medulla oblongata while no effect on blood flow was observed in the pituitary gland. Significance of these results reside in the potential role of methionine enkephalin as a modulator of blood flow to the brain.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
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