ZIB

Hits per page

hits 1 - 2 | 2 hits

Sorting

Electronic Resource

A physiological model for the pharmacokinetics of methylene chloride in B6C3F1 mice following i.v. administrations (1984)

Angelo, Michael J. ; Bischoff, Kenneth B. ; Pritchard, Alan B. ; [et al.]

Springer

Journal of pharmacokinetics and pharmacodynamics 12 (1984), S. 413-436

add to mindlist on the mindlist

Details

ISSN: 1573-8744

Keywords: methylene chloride ; pharmacokinetics ; physiological model ; hybrid model ; I.V. administrations ; mice

Source: Springer Online Journal Archives 1860-2000

Topics: Chemistry and Pharmacology

Notes: Abstract A physiologic mathematical model was developed to describe the time course of14C-methylene chloride (14CH2Cl2) distribution and elimination in mice following single i.v. administrations of 10 and 50mg/kg. A whole-body model was used to simulate14CH2Cl2 concentrations in blood and tissues, pulmonary clearance of unchanged14CH2Cl2, and metabolic conversion to14CO2 and14CO as monitored by the appearances of these metabolites in expired breath. This diffusion-limited model was identified via a sequential optimization scheme using hybrid models for each compartment. Pulmonary elimination of unchanged14CH2Cl2 was modeled as a linear process while hepatic metabolism of14CH2Cl2 to the compounds14CO2and14CO was described by a saturable metabolic rate term. The model adequately described the dose dependence in methylene chloride distribution and metabolism when simulations were compared to experimental data.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF01062666

Permalink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Paper (German National Licenses)

Fulltext

Electronic Resource

High-density and optical non-linearity effects in epitaxially grown ZnTe layers (1994)

Wagner, H. P. ; Festner, S. ; Stanzl, H. ; [et al.]

New York, NY [u.a.] : Wiley-Blackwell

Advanced Materials for Optics and Electronics 3 (1994), S. 33-39

add to mindlist on the mindlist

Details

ISSN: 1057-9257

Keywords: High-density luminescence ; Non-linear transmission ; ZnTe ; Metal-organic vapour phase epitaxy ; Inelastic exciton scattering ; Electron-hole plasma ; Pump-and-probe method ; Exciton screening ; Band gap renormalization ; Chemistry ; Polymer and Materials Science

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Electrical Engineering, Measurement and Control Technology , Physics

Notes: We investigated the high-density luminescence and non-linear transmission of ZnTe layers grown by metal-organic vapour phase epitaxy (MOVPE). For the high-density luminescence we compared ZnTe layers on (001) GaAs substrate with free-standing ZnTe layers of equal thickness. At high excitation intensities a strong luminescence P band appears a few meV below the free exciton energy which is assigned to resonant exciton-scattering processes. A second strong luminescence N band occurs only in free-standing layers. It shows a remarkable red shift with increasing intensity and becomes the dominant emission for an excitation intensity Iexc 〉 1.5 MW cm-2. This lower-energy band was interpreted as electron-hole plasma recombination.The optical non-linearity of thin ZnTe layers in the excitonic region was investigated by pump-and-probe experiments at 2 K and room temperature (RT). For these experiments we used two different pump energies, one above (at 2 K and RT) and one below (at 2 K) the band gap energy. In all cases a red shift and a large non-linear decrease in the excitonic absorption with increasing pump intensity was observed. The experimental results can be explained by many-body effects of exciton screening.

Additional Material: 6 Ill.