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  • 1
    Electronic Resource
    Electronic Resource
    Effect of spatial arrangement of the basement membrane on cultured pleomorphic adenoma cells. Study by immunocytochemistry and electron and confocal microscopy (1997)
    Springer
    Virchows Archiv 430 (1997), S. 467-477 
    Details
    ISSN: 1432-2307
    Keywords: Key words Salivary gland neoplasms ; Myoepithelial cell ; Extracellular matrix ; Matrigel
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  In a cell line from human pleomorphic adenoma (AP2 cells) we studied the response of these cells to basement membrane proteins. The culture was characterized as myoepithelial-like by transmission electron microscopy and immunocytochemistry. AP2 cells were grown in contact with a reconstituted basement membrane (Matrigel). Cells grown on Matrigel showed conspicuous phenotypic alterations, depending on how the substrate was applied. Cells grown on the top of Matrigel developed a dendritic phenotype, exhibiting thin, long and intercommunicating cytoplasmic extensions resembling normal myoepithelial cells. Cells grown inside Matrigel formed multi-layered clusters. Light, confocal and transmission electron microscopy showed that these clusters were formed by double-layered epithelioid cells delimiting luminal spaces. The cells facing the lumen were cuboidal, showing microvilli at the apical plasmalemmal and junctional complexes. The spatial arrangement of basement membrane is a key modulator of morphogenetic changes and cytodifferentiation of tumour myoepithelial cell lineage in culture.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004280050057
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Time-related variation of non-protein sulfhydryl concentrations in rat tissues and human blood (1979)
    Springer
    International archives of occupational and environmental health 42 (1979), S. 141-148 
    Details
    ISSN: 1432-1246
    Keywords: Non-protein sulfhydryl concentration ; Liver ; Lung ; Kidney ; Blood ; Rat ; Human ; Glutathione
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The concentration of non-protein sulfhydryl compounds (NPSH) were measured at various times of the day in rat blood, liver, lung, and kidney as well as in human blood. In each of these cases, there was a significant (p 〈 0.05) 24 h concentration variation. The variation in rat liver non-protein sulfhydryl concentration, with a maximum around the noon-time period and a minimum around midnight, appeared to be related to food intake. Blood, lung, and kidney concentrations were not similarly related to food intake. No simple, linear correlation could be shown between tissue non-protein sulfhydryl concentration among the four rat tissues. Thus, rat blood NPSH does not predict rat tissue NPSH concentrations. In seven normal human volunteers, four males and three females, significant 24 h variations in blood NPSH concentrations were observed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00377768
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    Paper (German National Licenses)
    Fulltext
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