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  • 1
    Electronic Resource
    Electronic Resource
    Antisecretory effect of DS-4574, a mast cell stabilizer with peptidoleukotriene antagonism, on gastric acid secretion in the pig (1994)
    Springer
    Inflammation research 41 (1994), S. 17-20 
    Details
    ISSN: 1420-908X
    Keywords: DS-4574 ; Mast cell stabilizer ; Gastric acid secretion ; Carbachol ; Tetragastrin ; Histamine ; Goettingen miniature pigs
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The antisecretory effect of DS-4574, a mast cell stabilizer with peptidoleukotriene antagonism, on the hypersecretion of gastric acid stimulated by several secretagogues was examined in the pig. Goettingen miniature pigs with chronic gastric fistula were used. Intramuscular injection of carbachol (60 μg/kg), tetragastrin (50 μg/kg) or histamine (200 μg/kg)-induced gastric acid hypersecretion. Intraduodenal administration of DS-4574 (10 and 20 mg/kg) significantly inhibited both the hypersecretion induced by carbachol and that by tetragastrin. On the other hand, DS-4574 (50 mg/kg, intraduodenal) did not suppress histamine-induced hypersecretion. In thein vitro study, no effect on hog gastric K+-dependent ATPase activity was found at concentrations of DS-4574 from 10−7 to 10−4 M. These results were highly similar to those in the rat. The suppression of histamine release from histamine-containing cells in the gastric mucosa of the rat was concluded to be an antisecretory effect of DS-4574.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01986387
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  • 2
    Electronic Resource
    Electronic Resource
    Inhibitory effect of DS-4574, a peptidoleukotriene antagonist with mast cell stabilizing action, on compound 48/80-induced gastric mucosal lesions in rats (1994)
    Springer
    Inflammation research 41 (1994), S. 21-24 
    Details
    ISSN: 1420-908X
    Keywords: DS-4574 ; Mast cell stabilizer ; Compound 48/80 ; Gastric mucosal lesions ; Disodium cromoglycate ; LY171883 ; Cimetidine ; Rats
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We evaluated the inhibitory effect of DS-4574, a peptidoleukotriene antagonist with mast cell stabilizing action, on rat gastric mucosal lesions induced by compound 48/80 (C48/80: a mast cell degranulator), in comparison with those of disodium cromoglycate (DSCG: a mast cell stabilizer), LY171883 (a peptidoleukotriene antagonist) and cimetidine (a histamine H2 receptor antagonist). Subcutaneous administration of C48/80 (1 mg/kg) once daily for four consecutive days produced extensive gastric lesions in the fundic mucosa. DS-4574 (20, 50 and 100 mg/kg/day, oral) and DSCG (200 mg/kg/day, intraperitoneal) treatment markedly inhibited formation of these mucosal lesions, but LY171883 (100 and 200 mg/kg/day, oral) and cimetidine (400 mg/kg/day, oral) treatment did not. Moreover, DS-4574 and DSCG significantly suppressed both hyperhistaminemia and histamine release from rat peritoneal mast cells induced by C48/80. These results indicate that the inhibitory effect of DS-4574 on gastric lesions induced by C48/80 may be related to its mast cell stabilizing action, but to neither its antisecretory nor its peptidoleukotriene antagonistic activity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01986388
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Familial amyotrophic lateral sclerosis: Features of multisystem degeneration (1984)
    Springer
    Acta neuropathologica 64 (1984), S. 22-29 
    Details
    ISSN: 1432-0533
    Keywords: Famihal ALS ; Oculomotor impairment ; Urinary disturbance ; Multisystemic degeneration
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Two sibling cases of familial amyotrophic lateral sclerosis (ALS) revealed degerneration usually associated with other systemic degenerative disorders. The changes in the 41-year-old sister were compatible with those reported in other familial ALS cases affecting the upper and lower motor neurons, posterior columns, and spinocerebellar tracts. The 45-year-old sister revealed more wide-spread degenerative changes involving not only motor neuron systems, but also proprioceptive, general somatic afferent and spinocerebellar afferent systems. Intracytoplasmic hyaline inclusions were observed in the oculomotor nuclei. Clinical manifestations of urinary disturbance and oculomotor imparirment seldom seen in sporadic ALS were interpreted to be due to the unusual distribution of the morbid process. These pathologic findings suggest that familial ALS may be a multisystemic degenerative disorder, frequently involving the spinocerebellar tracts, but occasionally involving other systems as well.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00695602
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    Paper (German National Licenses)
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