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  • 1
    Electronic Resource
    Electronic Resource
    Antisecretory effect of DS-4574, a mast cell stabilizer with peptidoleukotriene antagonism, on gastric acid secretion in the pig (1994)
    Springer
    Inflammation research 41 (1994), S. 17-20 
    Details
    ISSN: 1420-908X
    Keywords: DS-4574 ; Mast cell stabilizer ; Gastric acid secretion ; Carbachol ; Tetragastrin ; Histamine ; Goettingen miniature pigs
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The antisecretory effect of DS-4574, a mast cell stabilizer with peptidoleukotriene antagonism, on the hypersecretion of gastric acid stimulated by several secretagogues was examined in the pig. Goettingen miniature pigs with chronic gastric fistula were used. Intramuscular injection of carbachol (60 μg/kg), tetragastrin (50 μg/kg) or histamine (200 μg/kg)-induced gastric acid hypersecretion. Intraduodenal administration of DS-4574 (10 and 20 mg/kg) significantly inhibited both the hypersecretion induced by carbachol and that by tetragastrin. On the other hand, DS-4574 (50 mg/kg, intraduodenal) did not suppress histamine-induced hypersecretion. In thein vitro study, no effect on hog gastric K+-dependent ATPase activity was found at concentrations of DS-4574 from 10−7 to 10−4 M. These results were highly similar to those in the rat. The suppression of histamine release from histamine-containing cells in the gastric mucosa of the rat was concluded to be an antisecretory effect of DS-4574.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01986387
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  • 2
    Electronic Resource
    Electronic Resource
    Identification of 10-formyltetrahydrofolate, tetrahydrofolate and 5-methyltetrahydrofolate as major reduced folate derivatives in rat bile
    Amsterdam : Elsevier
    Journal of Chromatography B: Biomedical Sciences and Applications 620 (1993), S. 39-46 
    Details
    ISSN: 0378-4347
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0378-4347(93)80049-A
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Identification of 5,10-methylenetetrahydrofolate in rat bile
    Amsterdam : Elsevier
    Journal of Chromatography B: Biomedical Sciences and Applications 661 (1994), S. 237-244 
    Details
    ISSN: 0378-4347
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0378-4347(94)00342-4
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Doubtful roll of endogenous gastrin in chicken gastric secretion by vagal stimulation (1975)
    Springer
    Cellular and molecular life sciences 31 (1975), S. 197-198 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Zusammenfassung Nachweis, dass i.v. Tetragastrin (TG) und elektrische Vagusreizung eine stark erhöhte Magensekretion bei narkotisierten Hühnern und Ratten verursachte. Proglumid, ein Antigastrinikum, unterdrückte die Wirkung von TG bei beiden Tierarten, während die vermehrte Sekretion durch Vagusreizung nur bei Ratten, nicht aber bei Hühner, von Proglumid unterdrückt wurde.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01990703
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  • 5
    Electronic Resource
    Electronic Resource
    Effect of albumin distribution (1989)
    Springer
    Pharmacy world & science 11 (1989), S. 87-91 
    Details
    ISSN: 1573-739X
    Keywords: Albumin ; Clearance ; Distribution ; Midazolam ; Models, theoretical ; Pharmacokinetics ; Protein binding
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract The effects of altered albumin distribution on the apparent volume of distribution (V) and the apparent elimination rate constant (k) of drugs were investigated by a simulation analysis. The Equations derived by Øieet al. were modified for this purpose. Within the range observed in normal healthy subjects and patients, the change in albumin distribution significantly affectedV of drugs but, in general, notk. For drugs with more than 90% plasma-protein binding,V changed by more than 100%. The change in plasma-protein binding caused by an altered albumin distribution produced a greater effect onV than that caused by an altered albumin amount. These results suggest that albumin distribution is an important factor in controlling the kinetics of drugs which are highly bound to plasma protein. This is illustrated using midazolam as an example.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02110255
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  • 6
    Electronic Resource
    Electronic Resource
    Functional significance of histologic alterations induced by Escherichia coli pig-specific, mouse-negative, heat-stable enterotoxin (STb) (1987)
    Springer
    Veterinary research communications 11 (1987), S. 41-55 
    Details
    ISSN: 1573-7446
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In contrast to cholera enterotoxin and other Escherichia coli enterotoxins, a pig-specific, heat-stable E. coli enterotoxin (STb) causes morphologic lesions (loss of villous epithelial cells and partial villous atrophy). These lesions reflect a loss of absorptive cells and thus suggest that STb causes impaired absorption as well as inducing net secretion. The present studies assess functional significance of morphologic changes induced by STb. Net fluid movement, mucosal surface area, sucrase activity and the electrical response induced by alanine were measured in swine jejunal loops exposed to E. coli culture filtrates with and without STb. Net fluid secretion (-11.1±1.1 ml) occurred in some STb loops (secretors) and net absorption (2.7±0.3 ml) in others (nonsecretors), but net absorption occurred in all control loops (4.9±0.2 ml). The mucosal surface area of Stb loops was about 20% less than that of controls (P〈0.01). Sucrase activity was also lower (about 15%) in STb loops than in control loops (P〈0.01). The electrical response induced by alanine in mucosa from nonsecreting STb loops did not differ from that induced in mucosa from control loops. However, the response to alanine in mucosa from secreting STb loops was reduced about 70% from that in mucosa from nonsecreting STb loops or from control loops (P〈0.05). It is concluded that reduced sucrase activity is a functional correlate to villous atrophy induced by STb, that STb impairs alanine absorption in some loops (secretors), and that the impaired alanine absorption is independent of the decreased surface area caused by Stb. Because the impaired alanine absorption occurred independent of the decreases in surface area, it is suggested that the secretory response to STb is associated with an impairment of active absorption of alanine.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00361325
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