ISSN:
1435-1463
Keywords:
Clozapine
;
MK-801
;
eticlopride
;
haloperidol
;
NMDA receptors
;
stereotypy
;
locomotion
;
dopamine
;
glutamate
;
D 2 receptors
;
schizophrenia
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary The effects of typical and atypical neuroleptics on MK-801-induced locomotor activity and stereotyped sniffing were tested. Pretreatment with the typical neuroleptic haloperidol (0.01,0.05, 0.1,0.5 mg/kg SC) and the dopamine D 2 receptor selective antagonist eticlopride (0.005, 0.01, 0.05 mg/kg SC) each resulted in significant and dose-dependent reductions of locomotor activity and sniffing. The atypical neuroleptic clozapine (1.0, 5.0, 10.0 mg/kg SC) was some-what unique in that all doses reduced locomotor activity, but only the highest dose (10.0 mg/kg) significantly reduced sniffing. The data support a functional interaction between glutamate and dopamine systems, and suggest that the behavioral activation associated with MK-801 may represent a valid model for detecting potential therapeutic agents in the treatment of schizophrenia. The data should be viewed as preliminary, however, until neuroleptics are characterized in other glutamate-based models that minimize or exclude the possible influence of nonspecific motor effects.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01245347
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