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  • 1
    Digitale Medien
    Digitale Medien
    Differential diagnosis of fever in systemic lupus erythematosus using discriminant analysis (1986)
    Springer
    Rheumatology international 6 (1986), S. 69-77 
    Details
    ISSN: 1437-160X
    Schlagwort(e): Systemic lupus erythematosus ; Fever ; Serum globulin fractions ; Discriminant analysis
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary In an attempt to find a reliable method to assess fever in patients with systemic lupus erythematosus (SLE), a multifactorial analysis was applied to the routine laboratory examinations, including white blood cell count (WBC) and serum globulin fraction concentrations. During 74 febrile episodes, 49 SLE patients showed increased disease activity and the remaining 25 febrile episodes were due to intercurrent infection. The two different groups of fever episodes were clearly separated by a principal component analysis using five variables from the routine laboratory tests, including WBC, serum alpha-1, alpha-2, beta, and gamma globulins. Discriminant analysis showed that 95% of 74 febrile episodes could be correctly classified as to the cause of fever when a combination of WBC and alpha-2 globulin level was used as variables. A simple discriminant formula which we calculated was considered to be of practical use for the differentiation of the two clinical entities.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00541508
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  • 2
    Digitale Medien
    Digitale Medien
    Determination of the immunosuppressive drug tacrolimus in its dosage forms by high-performance liquid chromatography (1995)
    Springer
    Chromatographia 40 (1995), S. 253-258 
    Details
    ISSN: 1612-1112
    Schlagwort(e): Column Liquid Chromatography ; Immunosuppessive drug FK 506 (Tacrolimus) ; Tautomeric Phenomenon
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Summary A high-performance liquid chromatographic (HPLC) method has been developed and validated for the determination of FK506, a new immunosuppressant, in bulk drug samples and dosage forms. Equilibration between FK506 (I) and its tautomeric compounds (II and III) was accomplished “artificially” in water-dehydrated alcohol (1∶1) employed as an extraction solvent. After reaching equilibrium, separation of I, treated as the representetive of equilibrated FK506, from its related substances was achieved by reversed-phase HPLC on a C18 column with water-isopropyl alcohol-tetrahydrofuran (5∶2∶2, v/v) as the mobile phase, and detection at 220 nm. Component I in dosage forms could be recovered satisfactorily and determined with good precision. The calibration graph was linear over the range 2–6 μg for I.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02290354
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