ISSN:
1432-0878
Keywords:
Mitochondria Mammalian muscle
;
Calcium uptake
;
Formation of septa
;
Ultrastructure
;
Ionophore
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Summary Treatment of mammalian muscle with the divalent cation ionophore A23187 causes the release of Ca2+ from the sarcoplasmic reticulum and allows the ultrastructural changes of the mitochondria during Ca2+-uptake to be demonstrated in situ. Electron micrographs reveal that the mitochondria swell dramatically during uptake, before contracting again when the accumulated Ca2+ is released once more into the cytoplasm. When maximally swollen, the mitochondria are apparently subdivided and internal “septa” are formed. The ultrastructural details concerning these internal membranous structures are shown in detail and their significance is discussed.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00220297
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