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  • 1
    Digitale Medien
    Digitale Medien
    Properties of the Ca2+-ATPase activity of mammalian synaptic membrane preparations (1976)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 27 (1976), S. 0 
    Details
    ISSN: 1471-4159
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1471-4159.1976.tb00344.x
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  • 2
    Digitale Medien
    Digitale Medien
    Aids in Higher Education (1971)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of educational technology 2 (1971), S. 0 
    Details
    ISSN: 1467-8535
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Pädagogik
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1467-8535.1971.tb00560.x
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  • 3
    Digitale Medien
    Digitale Medien
    Eosinophils from patients with asthma express higher levels of the pan-leucocyte receptor CD45 and the isoform CD45RO (2003)
    Oxford, UK : Blackwell Science Ltd
    Clinical & experimental allergy 33 (2003), S. 0 
    Details
    ISSN: 1365-2222
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Background Eosinophils and their secreted mediators are heavily implicated as effector cells in asthma and other allergic diseases. Comparisons were made between expression of CD45, CD45RA, CD45RB and CD45RO by eosinophils from asthmatic patients and non-asthmatic atopic and non-atopic, non-asthmatic control subjects.Methods Twenty-seven patients with asthma and 33 control subjects were recruited for the study. Eosinophil expression of CD45, CD45RA, CD45RB and CD45RO was established by immunostaining and flow cytometry was performed on whole leucocyte samples. Eosinophil apoptosis in response to CD45 and CD45 isoform monoclonal antibody (mAb)-dependent receptor ligation was assessed by binding of annexin V and flow cytometry.Results Eosinophils from patients with asthma expressed significantly (P〈0.05) higher levels of pan-CD45 and CD45RO compared with eosinophils from non-asthmatic, non-atopic subjects. No significant correlations were found between expression of either pan-CD45 or CD45RO and the degree of symptoms in the asthmatic patients as defined by lung function (FEV1 and FEF25–75) and methacholine PD20. Increased expression of pan-CD45 or CD45RO did not appear to be a consequence of the atopic phenotype. Higher expression of pan-CD45 or CD45RO by eosinophils from asthmatic patients was not associated with greater sensitivity to CD45 and CD45RO mAb receptor ligation-induced eosinophil apoptosis.Conclusion Higher expression of CD45 and CD45RO by eosinophils from asthmatic patients appeared to be a consequence of asthma rather than atopy and further supports a role for activated eosinophils in asthma.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1046/j.1365-2222.2003.01697.x
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  • 4
    Digitale Medien
    Digitale Medien
    Rhythmic activity in an isolated penis preparation from the freshwater snail Limnaea stagnalis (1964)
    Springer
    Journal of comparative physiology 48 (1964), S. 295-301 
    Details
    ISSN: 1432-1351
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Beschreibung / Inhaltsverzeichnis: Zusammenfassung 1. Die rhythmische Aktivität des isolierten Penis-Komplexes der Wasserschnecke Limnaea stagnalis wird beschrieben. 2. Das Präparat antwortet auf Acetylcholin, Adrenalin, 5-HT und GABA; die Bedeutung dieser Ergebnisse wird diskutiert. 3. Die Ergebnisse zeigen deutliche Unterschiede zu jenen, die an einem ähnlichen Präparat von einem stylommatophoren Pulmonaten erzielt wurden.
    Notizen: Summary 1. Rhythmic activity of the isolated penial complex of the freshwater snail Limnaea stagnalis is described. 2. The preparation responds to acetylcholine, adrenaline, 5-HT and GABA, and the significance of these results is discussed. 3. The results show marked differences from those obtained with a similar preparation from a stylommatophoran pulmonate.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00339458
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  • 5
    Digitale Medien
    Digitale Medien
    Stimulation of the frequency of MEPPs at the frog neuromuscular junction by extracellular EGTA (1980)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 315 (1980), S. 29-35 
    Details
    ISSN: 1432-1912
    Schlagwort(e): Calcium ; Neuromuscular junction ; Spontaneous release ; MEPP
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Exposure of the frog neuromuscular junction at 17° C or 23° C to salines with low [Ca2+], buffered with EGTA, causes mepp frequency to fall after 4–6 min to about 20% of the control rate. Results obtained in the presence of verapamil suggest that this fall is a consequence of a lower Ca2+-influx coupled with the action of the extracellular EGTA in promoting Ca2+-efflux from the terminals. These findings confirm the suggestion that [Ca2+]i has a major role in determining mepp frequency. At 13° C, the fall in mepp frequency after addition of EGTA is preceded by a transient (1–2 min) rise in mepp rate which is not present at 17° C or in the presence of verapamil. This transient acceleration in spontaneous release is believed to be because EGTA promotes the emptying of a Ca2+-reservoir on or beneath the inner face of the membrane, thus causing a rapid Ca2+-efflux via the Ca2+-sensitive sites that trigger exocytosis of transmitter. The significance of the sensitivity of the response to temperature is discussed. The suppressive effect of higher temperatures can be reversed to some extent by hyperosmotic salines, an effect that may reflect the action of hypertonicity on the plasmalemma. It is concluded that the characteristics of the release system may change markedly at about 16° C. Ca2+-EGTA buffers are widely used; it is suggested that extracellular EGTA can also modify [Ca2+]i in cellular systems.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00504227
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  • 6
    Digitale Medien
    Digitale Medien
    The action of lindane in accelerating the spontaneous release of transmitter at the frog neuromuscular junction (1979)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 308 (1979), S. 179-182 
    Details
    ISSN: 1432-1912
    Schlagwort(e): Lindane ; neuromuscular junction ; transmitter release ; calcium
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Lindane (5×10−5M) causes a progressive and marked rise in MEPP frequency at the frog neuromuscular junction. Concentrations over a range of 5×10−6M to 5×10−4M were tested. The results suggest that it has two actions in promoting this effect. Its major effect is probably to cause an increase in Ca2+-permeability and a rise in Ca2+ entry. Its second, smaller effect, which persists in the absence of extracellular Ca2+, is probably also because of a rise in [Ca2+]i. The ways in which these effects might be produced and the significance of these findings for explaining the known pharmacological actions of lindane are discussed.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00499062
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  • 7
    Digitale Medien
    Digitale Medien
    2,4-dinitrophenol, lysosomal breakdown and rapid myofilament degradation in vertebrate skeletal muscle (1980)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 315 (1980), S. 77-82 
    Details
    ISSN: 1432-1912
    Schlagwort(e): Muscle ; Lysosomes ; Calcium ; Muscular dystrophy
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary 1. The possibility that rapid Ca2+-uptake by skeletal muscle mitochondria may cause local reductions in pH i (by H+/Ca2+ exchange) and so promote lysosomal breakdown has been explored using amphibian and mammalian preparations. Recent studies suggested that such a sequence of events is possible in cardiac muscle. 2. However, extensive muscle damage can still be initiated in skeletal muscle when the mitochondria are uncoupled so that Ca2+-uptake is prevented. 3. DNP alone induces extensive myofilament degradation which is similar to that produced by A 23187 and caffeine and described previously. 4. It is suggested that (a) the known action of DNP in promoting lysosomal labilization in living cells is produced by mitochondrial uncoupling and the release of stored Ca2+, (b) raised [Ca2+] i promotes lysosomal breakdown in skeletal muscle, so that the hydrolases released effect myofilament dissolution rapidly. 5. DNP also rapidly causes septation and division of the mitochondria in mammalian skeletal muscle.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00504233
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  • 8
    Digitale Medien
    Digitale Medien
    The action of caffeine in promoting ultrastructural damage in frog skeletal muscle fibres (1978)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 305 (1978), S. 159-166 
    Details
    ISSN: 1432-1912
    Schlagwort(e): Caffeine ; Muscle ; Muscular dystrophy ; Calcium ; A23187
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary 1. Caffeine at concentrations above 5 mM was shown to cause rapidly extensive ultrastructural damage to the myofibrils of frog skeletal muscle. 2. The effect was promoted at lower temperatures, whereas the myofibrils were protected by prior exposure to procaine. 3. It is argued that caffeine causes a Ca2+-induced release of Ca2+ (the CROC) from the S.R. and that the consequent rise in [Ca2+]i promotes the ultrastructural damage observed. 4. Myofibril degradation is also produced by treatment of the muscle with the divalent cation ionophore A23187; this effect is not protected by either procaine or Dantrolene sodium. 5. It is suggested that A23187 causes the release of Ca2+ from the S.R. by a mechanism that differs from both excitation and the CROC; the resultant rise in [Ca2+]i again causes myofibril degradation. 6. The ways in which a marked rise in [Ca2+]i could cause muscle damage and the possible relevance of these findings to the sequence of events in the development of myopathies of human skeletal muscle are discussed.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00508287
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  • 9
    Digitale Medien
    Digitale Medien
    The transducer mechanism of sense organs (1964)
    Springer
    Naturwissenschaften 51 (1964), S. 172-173 
    Details
    ISSN: 1432-1904
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Chemie und Pharmazie , Allgemeine Naturwissenschaft
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00622309
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  • 10
    Digitale Medien
    Digitale Medien
    The action of ouabain in promoting the release of catecholamines (1977)
    Springer
    Cellular and molecular life sciences 33 (1977), S. 923-924 
    Details
    ISSN: 1420-9071
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Notizen: Summary It is suggested that ouabain promotes catecholamine release by causing a rise in intracellular Na+ which, in turn, causes an elevated steady-state level of intracellular Ca2+. It is suggested that the Na+−K+-ATPase is not directly involved in exocytosis at either adrenergic or cholinergic synapses.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01951283
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