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  • 1
    Electronic Resource
    Electronic Resource
    Resistance to ischaemic nerve-fibre block in diabetes mellitus and in mitochondrial encephalomyopathies (1993)
    Springer
    Journal of neurology 240 (1993), S. 87-92 
    Details
    ISSN: 1432-1459
    Keywords: Ischaemic conduction block ; Small fibre function ; Thermal perception ; Resistance to ischaemia ; Mitochondrial encephalomyopathy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Thermal thresholds were measured during ischaemic compression block in the left forearms of 26 healthy subjects, 10 patients with diabetes mellitus and 6 patients suffering from different kinds of mitochondrial disorders. Cold and warm thresholds in the 6 patients with deficiencies in the respiratory chain increased earlier than in normals. When cold perception was impaired, cold stimuli were perceived as warmth and pinprick perception attenuated. In diabetics cold thresholds were less elevated during ischaemic block than in controls. This was paralleled by tingling paraesthesiae in all groups. The findings show that higher resistance to ischaemic nerve-fibre block in diabetes mellitus is not exclusively based on increased anaerobic metabolism.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00858723
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Resistance to ischaemia of small afferent nerve fibres in diabetes mellitus (1990)
    Springer
    Journal of neurology 237 (1990), S. 295-299 
    Details
    ISSN: 1432-1459
    Keywords: Diabetic polyneuropathy ; Ischaemic conduction block ; Pain ; Small fibre function ; Thermal perception
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Thermal thresholds were measured in the left forearms of 26 healthy subjects and 10 patients with diabetes mellitus during ischaemic compression block. During the period when ischaemic block of large fibres caused paraesthesia and loss of touch sensation, the cold threshold rose in normals. The cold threshold was less clearly elevated and the warm perception remained unaltered by ischaemia in diabetics. These results show that not only large afferent and efferent nerve fibres but also thinly myelinated Aδ and unmyelinated C fibres are resistant to ischaemia in the diabetic nerve.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00314745
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Glutamat- und GABA-Konzentration in Gehirn und Liquor Cerebrospinalis von Ratten unter Behandlung mit Phosphatidylcholin (1982)
    Springer
    European archives of psychiatry and clinical neuroscience 232 (1982), S. 33-38 
    Details
    ISSN: 1433-8491
    Keywords: Phosphatidylcholine ; Glutamate ; GABA ; Brain ; CSF ; Friedreich's ataxia ; Phosphatidylcholin ; Glutamat ; GABA ; ZNS ; Liquor cerebrospinalis ; Friedreichsche Ataxie
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Um zu untersuchen, ob die Gabe von Phosphatidylcholin, die den zentralnervösen Azetylcholingehalt erhöht, einen Einfluß auf die Neurotransmitter Glutamat und GABA hat, wurde 17 von 32 Ratten über 14 Tage 1,5g/kg Lethicon® pro die peroral gegeben. Die fluorometrische Messung der Konzentrationen von Glutamat und GABA in frontalem Cortex, Striatum, Nigra, Kleinhirnrinde sowie von Glutamat im Liquor cerebrospinalis ließ keine signifikanten Unterschiede gegenüber Kontrolltieren erkennen. Nach zweiwöchiger Gabe von Phosphatidylcholin konnte keine zentralnervöse Interaktion des cholinergen Systems mit den Neurotransmittern Glutamat und GABA nachgewiesen werden.
    Notes: Summary Phosphatidylcholine increases CNS concentrations of acetylcholine. In rats we investigated whether or not phosphatidylcholine also influences the neurotransmitters glutamate and GABA. In 17 rats 1.5g/kg Lethicon perorally was administered daily for 2 weeks, 15 rats served as controls. In tissue from frontal cortex, striatum, substantia nigra, cerebellar cortex no significant differences between treated and untreated animals were found in glutamate or GABA concentrations. A central nervous interaction between the cholinergic system and the neurotransmitters glutamate and GABA, therefore, could not be demonstrated after 2 weeks of phosphatidylcholine intake.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00343363
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  • 4
    Electronic Resource
    Electronic Resource
    Computer-Tomografie bei Atrophien im Bereich der hinteren Schädelgrube (1980)
    Springer
    European archives of psychiatry and clinical neuroscience 229 (1980), S. 179-187 
    Details
    ISSN: 1433-8491
    Keywords: Computerized tomography ; Friedreich's ataxia ; Cerebellar atrophy ; Nonne-Marie's spastic ataxia ; Computertomographie ; Friedreich-Ataxie ; Kleinhirnatrophien ; Nonne-Marie-Syndrom
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Zur Differenzierung verschiedener Formen von Kleinhirnatrophien wurden axiale Computer-Tomogramme (CT) des Schädels bei 69 Patienten durchgeführt. Die größten Gruppen umfassen 45 Patienten mit Friedreichscher Ataxie und 14 Patienten mit idiopathischer oder symptomatischer Kleinhirnatrophie. Bei 4 Patienten konnte Morbus Nonne-Pierre Marie, einmal olivo-ponto-cerebelläre Atrophie diagnostiziert werden. Es wird gezeigt, daß das CT eine wesentliche Hilfe zur Unterscheidung der verschiedenen Krankheitsgruppen intra vitam darstellt und darüber hinaus eine recht sichere Differenzierung gegenüber anderen Krankheiten erlaubt. Die Atrophien sind unterschiedlich und zum Teil charakteristisch verteilt. Schwere Formen von Friedreichscher Ataxie gehen oft mit Atrophie von Oberwurm und Paravermis einher, sind also nicht rein spinal lokalisiert, was methodisch bedingt auch bei Sektionen oft makroskopisch nicht wahrzunehmen ist.
    Notes: Summary Cranial computerized tomography was carried out in 69 patients with cerebellar ataxia (45 with Friedreich's ataxia, 4 with Marie's spastic ataxia, 14 with cerebellar atrophy, and one patient with olivo-pontocerebellar atrophy). In CT scans cerebellar atrophy is found to be of various localisation and partially of characteristic distribution. CT, therefore, greatly helps to distinguish different types of cerebellar and spino-cerebellar atrophy and also distinguishes separate cerebellar atrophy of various origin from other diseases like multiple sclerosis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00343081
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    Paper (German National Licenses)
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