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  • 1
    Electronic Resource
    Electronic Resource
    Aging alterations in the modulation of central dopaminergic cilioinhibition by etorphine in the marine mussel,Mytilus edulis: Decrease in the inhibition of presynaptic dopamine release (1987)
    Springer
    Cellular and molecular neurobiology 7 (1987), S. 209-219 
    Details
    ISSN: 1573-6830
    Keywords: aging ; dopamine ; etorphine ; presynaptic ; Mytilus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary 1. This report further demonstrates that etorphine influences presynaptic dopamine release, which in turn centrally modulates peripheral cilioinhibition. 2. In older animals cilioinhibition has become enhanced due to a lack of responsiveness to endogenous opioids which results in greater dopamine release, causing a higher level of cilioinhibition as demonstrated by challenging the visceral ganglia with etorphine or destroying the dopaminergic component with 6-hydroxydopamine. 3. Only the central cilioinhibitory, not the peripheral inhibitory response, mechanism appears to be altered in older animals. Thus, the alteration appears in the central integrative mechanisms involved with regulating ciliary activity. 4. The KCl-stimulated release of dopamine is unaltered in both young and old organisms, whereas the opiate inhibition of the KCl-stimulated release of dopamine is reduced in older organisms. Thus, the aging-associated alteration is associated with a specific process. 5. The reduction of opioid influence and the resulting enhanced cilioinhibitory activity may make the organisms more susceptible to environmental stress.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00711555
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Cholinergic nerves stimulate mucociliary transport, ciliary activity, and mucus secretion in the frog palate (1982)
    Springer
    Cell & tissue research 227 (1982), S. 413-421 
    Details
    ISSN: 1432-0878
    Keywords: Frog palate ; Mucociliary transport ; Ciliary activity ; Mucus secretion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Mucociliary transport, ciliary activity, and mucus secretion were studied in the palate of the frog Rana pipiens by direct observation, stroboscopic synchronization of ciliary beating, and histochemistry. Excised palates were studied in vitro, and intact palates were studied in vivo. Electrical stimulation of the glossopharyngeal nerve in vivo or of the palatine nerve in vitro stimulated all three activities. The effect was mimicked by acetylcholine and pilocarpine, enhanced by physostigmine, and blocked by atropine but unaffected by d-tubocurarine. Stimulation increased the number of cilia beating and their rate of beating, the number of goblet cells secreting and, for small acidic cells, the amount of mucus secreted, and the rate and extent of particle transport. The response to tactile stimulation was locally restricted in vitro but widespread in vivo. It was concluded that, although there is a low basal rate of mucus secretion and ciliary activity that is independent of nervous control, stimulation of these activities in the intact animal is mediated through the central nervous system and cholinergic nerves to the palate.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00210895
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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