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  • GRF  (1)
  • Intercellular glycoconjugates  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Endorcine cells producing regulatory peptides (1987)
    Springer
    Cellular and molecular life sciences 43 (1987), S. 839-850 
    Details
    ISSN: 1420-9071
    Keywords: Bombesin ; substance P ; CRF ; ACTH ; opioids ; calcitonin ; somatostatin ; PP ; glucagon ; GRF ; secretin ; GIP ; gastrin ; CCK ; motilin ; neurotensin ; endocrine cells ; endocrine tumours
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Recent data on the immunologication of regulatory peptides and related propeptide sequences in endocrine cells and tumours of the gastrointestinal tract pancreas, lung, thyroid, pituitary (ACTH and opioids), adrenals and paraganglia have been revised and discussed. Gastrin, xenopsin, cholecystokinin (CCK), somatostatin, motilin, secretin, GIP (gastric inhibitory beenrevised and discussed. Gastrin, xenopsin, cholecystokinin (CCK), somatostatin, motilin, secretin, GIP (gastric inhibitory polypeptide), neurotensin, glicentin/glucagon-37 and PYY (peptide tyrosine tyrosine) are the main products of gastrointestinal endocrine cells; glucagon, CRF (corticotropin releasing factor), somatostatin, PP (pancreatic polypeptide) and GRF (growth hormone releasing factor), in addition to insulin, are produced in pancreatic islet cells; bombesin-related peptidesare the main markers of pulmonary endocrine cells; calcitonin and CGRP (calcitonin gene-related peptide) occur in thyroid and extrathyroid C cells; ACTH and endorphins in anterior and intermediate lobe pituitary cells, α-MSH and CLIP (corticotropoin-like intermediate lobe peptide) in intermediate lobe cells; met- and leu-enkephalins and related peptides in adrenal medullary and paraganglionic cells as well as in some gut (enterochromaffin) cells; NPY (neuropeptide Y) in adrenalin-type adrenal medullary cells, etc.. Both tissue-appropriate and tissue-inappropriate regulatory peptides are produced by endocrine tumours, with inappropriate peptides mostly produced by malignant tumours.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01945362
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Altered intercellular glycoconjugates and dilated intercellular spaces of esophageal epithelium in reflux disease (2000)
    Springer
    Virchows Archiv 436 (2000), S. 207-216 
    Details
    ISSN: 1432-2307
    Keywords: Key words Esophagus ; Esophagitis ; Reflux disease ; Intercellular glycoconjugates ; Intercellular space dilation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Background and aims: The usefulness of histological diagnosis of gastroesophageal reflux disease (GERD) is limited by poor specificity or sensitivity of available diagnostic tools. Recently, ultrastructural morphometry showed interstitial space dilation (ISD) to be a reliable sign of reflux disease. Aims of this study were to (a) search for a light microscopy equivalent of ISD, (b) test its diagnostic value, and (c) look for a possible role of intercellular glycoconjugates in its genesis. Methods: Esophageal grasp biopsies were taken during endoscopy, 2–3 cm and 6–7 cm above the squamo- columnar junction, from patients under investigation for GERD symptoms. The biopsies were fixed in aldehyde solutions and embedded in resin for electron microscopy or in paraffin for routine histology, and the glycoconjugates underwent immunohistochemistry using 3-fucosyl-N-acetylactosamine antibodies. Results: Irregular intercellular space dilation was detected in the basal and prickle layers using both light and electron microscopy. Hematoxylin–eosin preparations showed ISD in 20 of 22 (90%) erosive esophagitis cases, 30 of 44 (68%) endoscopy negative GERD cases, and 1 of 12 (8%) controls, with good interobserver (K=0.75) and bioptic site reproducibility. ISD correlated with loss or rearrangement of intercellular glycoconjugates of the overlying layers and with granulocyte (eosinophil and/or neutrophil) infiltration. Conclusions: Light microscopy ISD is a suitable index of GERD. Alterations of intercellular glycoconjugates are likely to have a role in the genesis of ISD and GERD.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004280050032
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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