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  • 1
    Electronic Resource
    Electronic Resource
    Carbamazepine and its 10,11-epoxide in children and adults with epilepsy (1977)
    Springer
    European journal of clinical pharmacology 11 (1977), S. 129-133 
    Details
    ISSN: 1432-1041
    Keywords: carbamazepine ; carbamazepine-10,11-epoxide ; plasma concentration ; CSF concentration ; children ; adult
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The plasma concentrations of carbamazepine and its 10,11-epoxide were measured in 37 children and 13 adults with epilepsy during maintenance therapy. The children formed relatively more of the epoxy metabolite than adults. The daily dose, expressed as mg/kg or mg/m2, showed a statistically significant correlation with blood level in children, but not in adults. The cerebrospinal fluid concentrations of carbamazepine and carbamazepine-10,11-epoxide in nine children were 33 and 41 per cent, respectively, of the concomitant plasma level.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00562904
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Low-level determination of EDTA and DTPA in natural waters by gas chromatography (1996)
    Springer
    Chromatographia 42 (1996), S. 578-582 
    Details
    ISSN: 1612-1112
    Keywords: Gas chromatography ; EDTA determination ; DTPA determination ; Water analysis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary A new analytical method and the method validation for the determination of ethylenediaminetetraacetic acid (EDTA) and diethylenetriaminepentaacetic acid (DTPA) in lake and sea water is presented. An aqueous sample, after evaporation to dryness, was treated with an esterification reagent. The resulting ethyl ester derivates were determined by capillary gas chromatography using a nitrogen phosphorus specific detector (GC-NPD). The response was linear up to 5 mg L−1. The recoveries from lake and sea waters were 59–105 % for EDTA and 86–112 % for DTPA. The run-to-run repeatabilities (R.S.D.) were 2–8 % for EDTA and 4–11 % for DTPA depending on concentration and the reproducibilities (R.S.D.) were 6–13 % and 3–11 %, respectively. The limits of detection for EDTA and DTPA were 3 and 12 μg L−1 in distilled water, respectively. The method is simple to use and reliable as shown by the analysis of samples of lake water that is influenced by pulp and paper industry.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02290295
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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