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Finnish hereditary amyloidosis is caused by a single nucleotide substitution in the gelsolin gene

Maury, C.P.J. ; Kere, J. ; Tolvanen, R. ; [et al.]

Amsterdam : Elsevier

FEBS Letters 276 (1990), S. 75-77

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ISSN: 0014-5793

Keywords: DNA-test ; Familial amyloid polyneuropathy ; Finnish hereditary amyloidosis ; Gelsolin gene ; Oligonucleotide hybridization ; Point mutation

Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002

Topics: Biology , Chemistry and Pharmacology , Physics

Type of Medium: Electronic Resource

URL: http://linkinghub.elsevier.com/retrieve/pii/0014-5793(90)80510-P

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Evolution of zinc finger-Y and zinc finger-X genes in oryzomyne-akodontine rodents (Cricetidae) (1992)

Bianchi, N. O. ; Bianchi, M. S. ; Pamilo, P. ; [et al.]

Springer

Journal of molecular evolution 34 (1992), S. 54-61

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ISSN: 1432-1432

Keywords: Zfy-Zfx genes ; Gene evolution ; Oryzomyne-akodontine rodents

Source: Springer Online Journal Archives 1860-2000

Topics: Biology

Notes: Summary Zinc finger-Y (Zfy) and zinc finger-X (Zfx) genes were analyzed by Southern blotting in male and female specimens of 10 species belonging to the oryzomyne-akodontine stock of Cricetidae rodents. DNA fragments were used as characters to construct a parsimony tree of the genes. Zfx and Zfy trees in general coincide with the evolutionary history of the taxa. Both trees show Oryzomys longicaudatus genes as the outgroup whereas Akodon xanthorrhinus genes are also distant from those of the other species. Oxymycterus rufus and Bolomys obscurus share related sequences, while genes from the other six Akodon species form a group of their own. It was found that 9 out of the 10 species analyzed show Zfy amplification in a range varying from 2 to 24 copies and with a pattern that is clade specific. The estimation of the average changes per character strongly suggests that Zfy has evolved more rapidly than Zfx; our estimates of the rate of nucleotide substitution are 4.6 times higher for Zfy than for Zfx.