ISSN:
1432-1432
Keywords:
Alu subfamily
;
Annexins
;
BC200 gene
;
Calcium-binding protein
;
Gene structure
;
Genomic DNA
;
Molecular evolution
;
Molecular sequence data
;
Structural elements
;
Z-DNA
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
Notes:
Abstract We have identified two types of structural elements in genomic DNA for annexin I that provide physical evidence of genetic events leading to conserved changes in gene structure. The sequence upstream of the transcribed region in human annexin I contained a rare, Alu-like repetitive element with flanking direct repeats, probably derived from the active BC200 gene via germline retroposition. Nucleotide substitutions in this BC200 insert relative to the 7SL gene and its absence in rodent annexins I identified it as a recent primate pseudogene. Phylogenetic analysis showed that the BC200 gene represents a new clade of primate Alu evolution that branched near the time of appearance of the progenitor to the free left Alu monomer, FLAM-C. Separate analysis identified a Z-DNA motif in pigeon annexin I intron 7 that may represent the vestigial recombination site involved in primordial assembly of the annexin tetrad. These distinct structural features in annexin I genes provide insight into the evolution of Alu repeats and the mechanism of annexin tetrad formation.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00173179
Permalink
