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  • 1
    ISSN: 1432-0428
    Keywords: Gestational diabetes ; islet cell antibodies ; insulin autoantibodies
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Diabetes mellitus is a frequent transient or rare permanent complication of pregnancy. The role of autoimmune phenomena in this gestational form of diabetes is incompletely understood. We have examined sera from 312 pregnant women who had abnormal glucose tolerance (based on a screening examination during the second trimester) for the presence of islet cell surface antibodies or insulin autoantibodies. Fifty-eight of these women were lost to follow-up. Of the remaining subjects, 144 (57.1%) had gestational diabetes diagnosed by formal glucose tolerance testing and the others (42.9%) were normal. Sixty percent of the women with gestational diabetes eventually required insulin to control their blood glucose during pregnancy. One serum from the non-diabetic women was positive for insulin antibodies (0.9%);8 of the sera from the patients with gestational diabetes were positive (5.6%). Subsequent analysis revealed that all nine of the women whose sera were positive for insulin autoantibodies had been treated with insulin previously. Islet cell surface antibodies were strongly correlated with gestational diabetes. Forty-five of 144 gestational diabetic sera were positive (31.3%) whereas only 9 of 108 suspect control sera (8.3%) and 7 of 60 unknown sera (11.7%) were positive. These data suggest that a high percentage of pregnant women who screen positive for glucose intolerance have serological evidence of an autoimmune response against the pancreatic islets, in spite of the state of relative immune tolerance during pregnancy. These data suggest that autoimmune phenomena may play a role in gestational diabetes and that the presence of islet cell antibodies can predict insulin-requiring gestational diabetes.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    European radiology 10 (2000), S. 1745-1749 
    ISSN: 1432-1084
    Keywords: Key words: Contrast-enhanced MRA ; Coils ; Peripheral arteries ; Peripheral arteriosclerotic occlusive disease
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. In this paper we introduce a phased-array coil dedicated for MRA of peripheral arteries which covers the upper and lower legs. The structure of this coil includes a solid cabinet with four flexible wings forming a “T.” The flexibility of the wings allows adaptation to the individual leg size. There are eight circularly polarized channels, four on each side. This coil is compatible with other surface coils. For MRA of peripheral arteries, it is combined with the body phased-array coil and the spine array coil which cover the lower abdomen and the pelvis. We examined six patients using this coil combination. The image quality, the signal-to-noise ratio (SNR), and contrast-to-noise ratio (CNR) of these examinations were compared with that of peripheral MRA examinations obtained with the body resonator. Image quality with the array coil was considerably improved in comparison with the body resonator examinations. The SNR and CNR increased approximately 100 %. The handling of this coil was very quick and simple, similar to the procedure with other surface coils. The use of dedicated phased-array coils for peripheral MRA may be an important step toward the establishment of MR digital subtraction angiography (DSA) as a non-invasive alternative to intra-arterial DSA in the visualization of peripheral arteries. Its potential has to be evaluated in future studies.
    Type of Medium: Electronic Resource
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