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  • Polymer and Materials Science  (3)
  • Glutamate  (2)
  • therapy  (2)
  • 1
    Electronic Resource
    Electronic Resource
    Lamotrigine-antiparkinsonian activity by blockade of glutamate release? (1993)
    Springer
    Journal of neural transmission 5 (1993), S. 67-75 
    Details
    ISSN: 1435-1463
    Keywords: Glutamate ; excitatory neurotransmitter ; lamotrigine ; Parkinson's disease ; basal ganglia pathways
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Recent experiments provide evidence that the NMDA-antagonist MK-801 has a locomotor-stimulating effect in monoamine-depleted rodents. These findings are based upon a hypothetical pathway-circuit including the basal ganglia as a model reflecting hypo- and hyperkinetic movement disorders. We have treated 5 patients suffering from Parkinson's disease with the antiepileptic drug “lamotrigine” which does not appear to be an NMDA-antagonist but acts functionally as a glutamate antagonist by inhibition of presynaptic glutamate release.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02260916
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Treatment of parkinsonian tremor with clozapine (1990)
    Springer
    Journal of neural transmission 2 (1990), S. 233-238 
    Details
    ISSN: 1435-1463
    Keywords: Parkinson's disease ; clozapine ; tremor ; therapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary After preliminary obsevations on 5 psychotic and 7 nonpsychotic parkinsonian patients had shown unexpected impressive beneficial effects of the atypical neuroleptic clozapine on tremor, an open clinical study including 12 patients was started. Under a dosage-range ∼ 25–50 mg/day significant reduction of tremor intensity and tremor related functional disability (CURS, Sweet's scale) was achieved. Akinesia was not deteriorated, initial fatigue disappeared spontaneously. Pharmacological mode of action of clozapine's antitremor effect remains unclear. Its broad receptor binding spectrum with strong antiserotonergic properties might here play a major role.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02257654
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Lamotrigine in Parkinson's disease — a double blind study (1995)
    Springer
    Journal of neural transmission 10 (1995), S. 199-206 
    Details
    ISSN: 1435-1463
    Keywords: Glutamate ; glutamate release ; antiglutamatergic activity ; excitatory neurotransmitter ; Lamotrigine ; Parkinson's disease ; basal ganglia ; neurotransmission ; therapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Antiglutamatergic acting substances are considered to be useful tools for the treatment of hypokinesia in animal models for Parkinson's disease (PD). Moreover, most known antiglutamatergic compounds act postsynaptically and are either toxic or weak with regard to their clinical potency. The antiepileptic drug “Lamotrigine (LTG)” inhibits presynaptic glutamate release and may therefore provide a novel approach for PD therapy. Encouraging results from a pilot project led us to establish a placebo controlled trial including 20 patients with PD. The substance was generally well tolerated. There was a significant difference in the investigator's overall assessment of efficacy (6/10 vs. 2/10 improvement; p〈0.05) and a tendency for LTG to exhibit a beneficial effect in some registration parameters, but no significant differences in motor response were found between the two groups. We failed to confirm that LTG mediates a strong antiparkinsonian effect in this small study, but to clearly demonstrate slight or moderate beneficial effects larger groups are required.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02251231
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  • 4
    Electronic Resource
    Electronic Resource
    Vorbeugende und konstruktive Schutzmaßnahmen gegen Gas- und StaubexplosionenVortrag auf dem Jahrestreffen der Verfahrens-Ingenieure, 27. bis 29. Sept. 1978 in Aachen. (1979)
    Weinheim : Wiley-Blackwell
    Chemie Ingenieur Technik - CIT 51 (1979), S. 8-14 
    Details
    ISSN: 0009-286X
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Preventive and constructional measures against gas and dust explosions. Even during the planning of plant for processing potentially explosive products, process and constructional aspects should be accompanied by investigations on the products conducted with a view to obtaining as complete a picture as possible of the danger of explosion of the materials. These studies provide the basis for estimates of explosive risks in the plant and for decisions concerning the extent to which safety measures against the occurrence of explosions or the effects of explosions can be implemented. An explosion-proof plant can be accomplished by preventive measures hindering an explosion, or by constructional measures suppressing the effects of an explosion. This paper is intended to be of assistance in the choice of explosion-proofing equipment.
    Additional Material: 13 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/cite.330510105
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Thermally stimulated and isothermal depolarization currents in low-density polyethyleneReported in part at the Conference on Electrical Insulation and Dielectric Phenomena, Downingtown, Pa., Oct. 1974. (1976)
    New York : Wiley-Blackwell
    Journal of Polymer Science: Polymer Physics Edition 14 (1976), S. 531-542 
    Details
    ISSN: 0098-1273
    Keywords: Physics ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: Thermally stimulated and isothermal depolarization currents of three low-density polyethylenes are investigated in the temperature range 80-320°K. The thermally stimulated current spectra can be analyzed in terms of a continuous relaxation time spectrum. This spectrum can be resolved into three Gaussian distributions of activation energies centered near 140°K (γ-relaxation), 205°K, and 245°K (β-relaxation) in agreement with electrical and mechanical loss factor measurements. The experimental observation are explained in terms of reorienting dipoles, coupling the molecular motion to the electrical field.
    Additional Material: 9 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/pol.1976.180140313
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    Relaxation time spectrum of dipolar reorientation in low-density polyethyleneReported in part at the Conference on Electrical Insulation and Dielectric Phenomena, Downingtown, Pa., Oct. 1974. (1976)
    New York : Wiley-Blackwell
    Journal of Polymer Science: Polymer Physics Edition 14 (1976), S. 543-554 
    Details
    ISSN: 0098-1273
    Keywords: Physics ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: The Fröhlich model of discrete reorienting dipoles has been extended to include a continuous spectrum of relaxation times and applied to the measurement of thermally stimulated and isothermal depolarization currents of low-density polyethylenes. The experiments can only be interpreted if the detailed history of polarization and depolarization prior to the actual current measurements are taken into consideration. With certain simplification the spectrum of activation energies can be directly derived from the complete thermally stimulated current profile.
    Additional Material: 8 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/pol.1976.180140314
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    Paper (German National Licenses)
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