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Digitale Medien

Lamotrigine-antiparkinsonian activity by blockade of glutamate release? (1993)

Zipp, F. ; Baas, H. ; Fischer, P. -A.

Springer

Journal of neural transmission 5 (1993), S. 67-75

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Details

ISSN: 1435-1463

Schlagwort(e): Glutamate ; excitatory neurotransmitter ; lamotrigine ; Parkinson's disease ; basal ganglia pathways

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Summary Recent experiments provide evidence that the NMDA-antagonist MK-801 has a locomotor-stimulating effect in monoamine-depleted rodents. These findings are based upon a hypothetical pathway-circuit including the basal ganglia as a model reflecting hypo- and hyperkinetic movement disorders. We have treated 5 patients suffering from Parkinson's disease with the antiepileptic drug “lamotrigine” which does not appear to be an NMDA-antagonist but acts functionally as a glutamate antagonist by inhibition of presynaptic glutamate release.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF02260916

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