ISSN:
1432-0428
Keywords:
Insulin
;
insulin antibody
;
immunogenicity
;
immune response genes
;
haemocyanin
;
HLA
;
DR7
;
C2
;
C4
;
factor B
;
Gm
;
C-peptide
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Seventy-nine patients were observed prospectively during their initial period of treatment with conventional bovine insulins. Insulin antibody levels 6 months after starting insulin therapy did not correlate with age, gender or β cell function at onset of treatment. Patients who required soluble insulin in addition to isophane insulin developed higher levels of insulin antibody. Patients bearing the HLA-B8, DR3 and C4AQO alleles had lower levels of insulin antibody, whereas those bearing DR7 produced significantly higher levels. Other alleles at the C4A, C4B, C2, factor B or Gm loci did not appear to have a significant effect on insulin antibody production. The hyporesponsiveness of B8/DR3/C4AQO-positive individuals probably reflects a non-specific abnormality of immunity whereas the enhanced responsiveness of those positive for DR7 suggests the presence of a specific immune response gene for insulin
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00283648
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