ISSN:
1432-1912
Keywords:
Liver damage
;
Praseodymium
;
Serum lipoproteins
;
Hepatic lipoprotein secretion
;
Lecithin-cholesterol-acyltransferase
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary During liver damage induced by i.v. injection of 10 mg/kg praseodymium nitrate (Pr) marked alterations of the serum lipids are observed in female Wistar rats. The triglycerides (TG) decrease to about 50% of the control values after 2 days. Total phospholipids (TPL) and cholesterol (C) show a parallel time course: a 50% decrease 2 and 4 days after Pr is followed by a 50% increase at 4 days. The changes in the TPL are mainly due to alterations of phosphatidylcholine (PC) concentration, while the decrease in the concentration of C during the first 2 days is caused by a decrease of the esterified cholesterol (EC), whereas unesterified cholesterol (UC) is responsible for the subsequent increase of C. The fractionation of the serum lipoproteins (Lp) by sequential ultracentrifugation demonstrates a different response to Pr in each Lp class. At 2 days the very low density lipoprotein (VLDL) concentration decreases by 50%. Experiments with Triton WR 1339 show an inhibition of hepatic TG secretion at this time. On the other hand, the LDL increases to more than four times the controls, 4 days after Pr. The accumulating LDL are abnormally rich in UC and PC. Up to 2 days after Pr the high density lipoprotein (HDL) content declines to about 20% of the concentration in control animals. During the subsequent recovery the lipid pattern alters, as UC and TPL are increased; the HDL2 are particularly involved. Concomitant with the changes in the lipid patterns of LDL and HDL the activity of serum lecithin-cholesterol-acyltransferase (LCAT) decreases to about 15%, 3 days after Pr. From our results we conclude: (1) After Pr the VLDL, HDL and LCAT secretion of the liver is inhibited. (2) In the LDL, HDL, and less in the VLDL, UC and PC-rich Lp occur. This results in an alteration of the lipid pattern of the Lp. (3) The alteration of the lipid pattern is mainly due to the diminution of LCAT activity.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00501265
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