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  • 1
    Electronic Resource
    Electronic Resource
    S-100 protein positive cells in nasopharyngeal carcinoma (NPC): Absence of prognostic significance (1987)
    Springer
    Virchows Archiv 411 (1987), S. 233-237 
    Details
    ISSN: 1432-2307
    Keywords: S-100 Protein ; Langerhans cells ; Nasopharyngeal carcinoma ; Prognosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary An immunohistochemical study of S-100 protein in 43 nasopharyngeal carcinomas (NPC) of known clinical evolution (33 primary and 10 metastatic) is presented. Sixty per cent of primary site cases as well as all metastatic forms showed S-100 protein positive cells intermingled with tumour cells. These S-100 positive elements were identified as Langerhans cells. No significant differences were found when correlating S-100 protein positivity and histological NPC variants, neither in age nor in sex of patients. Statistical analysis failed to demonstrate any positive correlation between S-100 protein reactivity and clinical survival.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00735028
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Absence of p53 gene mutations in hepatocarcinomas from a Mediterranean area of Spain (1999)
    Springer
    Virchows Archiv 434 (1999), S. 497-501 
    Details
    ISSN: 1432-2307
    Keywords: Key words p53 mutation ; Hepatocellular carcinoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  The incidence of p53 gene abnormalities in human hepatocellular carcinoma (HCC) varies in different geographical areas, being higher in regions where hepatitis virus infection and dietary exposure to aflatoxin B1 are the most common aetiological agents. These mutations are less frequently encountered in Europe, although some studies have reported p53 protein overexpression in up to 45% of cases analysed. We have analysed 129 tumour samples of primary malignant hepatic neoplasms recovered from paraffin blocks processed in two pathology laboratories in a Mediterranean area of Spain (Valencia and Gerona). Among 14 cases in which p53 immunohistochemistry expression proved positive, 5 stained in more than 50% of the cell nuclei. By PCR-SSCP analysis we could detect the complete sequence from exon 5 through 8 in 70 cases and part of this region in the remaining cases, but no mutations were found. We found no relationship with the clinical stage, tumour stage or clinical outcome. We conclude that p53 gene alterations are not a major event in the malignant transformation of hepatic cells in this region of the Mediterranean. The variable incidence of p53 gene alterations in other geographical areas may reflect a different genetic background for the aetiology of HCC.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004280050374
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Histopathological predictive factors in Ewing's sarcoma of bone and clinicopathological correlations (1986)
    Springer
    Virchows Archiv 409 (1986), S. 627-640 
    Details
    ISSN: 1432-2307
    Keywords: Ewing's sarcoma ; Bone ; Histology ; Prognosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A retrospective multifactorial analysis on 261 previously untreated patients with Ewing's sarcoma (Es) of bone has been carried out in order to ascertain the prognostic value of several histological variables on survival. Among those cases accepted as Es, 208 (80% of the patients) were considered to be “typical Es”, while 40 (15%) displayed a large cell predominance, being subclassified as “atypical large cell Es”. Furthermore, 13 patients (5%) possessed tumours of endothelial-like appearance. Eleven cases which displayed a mixed histological configuration were finally included within one of the three previous groups according to their predominant histological pattern. After adjustment for therapeutic regimens and initial location of the tumour, only two histological characteristics remain significant; i.e. the presence of necrosis (p=0.002) and, to a lesser degree, the presence of filagree “en damier” pattern (p=0.08), both of which are of poor prognostic value. From this study, it can be assumed that the morphological (and possibly histogenetical) heterogeneity of Es of bone has no prognostic influence on survival.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00713429
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    Paper (German National Licenses)
    Fulltext
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