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  • 1
    Electronic Resource
    Electronic Resource
    Selective vulnerability in the gerbil hippocampus: Morphological changes after 5-min ischemia and long survival times (1990)
    Springer
    Acta neuropathologica 80 (1990), S. 18-25 
    Details
    ISSN: 1432-0533
    Keywords: Ischemia ; Hippocampus ; Resistant neurons ; Recirculation time
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The morphology of the hippocampus of Mongolian gerbils was investigated by light and electron microscopy after 5-min forebrain ischemia and survival times of up to 10 months. After 3 weeks recirculation only 5.8% of pyramidal neurons of the CA1 (cornu ammonis 1) sector had survived but the thickness of the inner and outer hippocampal layers did not change. After recirculation times of 6 and 10 months the number of surviving neurons declined no further but all layers of the CA1 subfield shrank markedly. Ultrastructurally, many but not all surviving CA1 neurons were altered. After 3 weeks both “dark” and “pale” type neurons were present, while after 6 and 10 months only the “pale” type of injury persisted. Axonal enlargements and myelin breakdown were observed at all survival times up to 10 months of recirculation. The astrocytes of CA1 sector contained numerous glial fibrils which were most pronounced after the longer recirculation times. The stratum radiatum presented intact presynaptic terminals densely packed with an abundance of clear vesicles even after survival of 10 months. Initially, morphologically damaged postsynaptic structures were still attached to these terminals but they disappeared after longer recirculation times. However, even after 10 months some intact synapses were observed involving dendrites which probably originated from surviving CA1 neurons. In CA3 sector and dentate gyrus no ultrastructural changes occurred at any survival time. The close association of surviving CA1 neurons with intact presynaptic terminals and reactive glial cells may be of importance for the development of epileptogenic foci which are characteristic of this particular brain region.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00294217
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  • 2
    Electronic Resource
    Electronic Resource
    The visualization and evaluation of bone architecture in the rat using three-dimensional X-Ray microcomputed tomography (1999)
    Springer
    Journal of bone and mineral metabolism 17 (1999), S. 37-44 
    Details
    ISSN: 1435-5604
    Keywords: Key words: bone ; rat ; 3-D X-ray microcomputed tomography ; histomorphometry ; bisphosphonate
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract: Microcomputed tomography allows the true three-dimensional structure of bone to be assessed by a nondestructive analysis. This article describes how this technique has for the first time been applied to rat bone to determine the effects of aging, ovariectomy, and antiresorptive drugs on bone structure and how these results compare with those determined by histological and histomorphometric techniques. During the procedure, a micro X-ray source is directed toward the bone sample. Modifications in the X-ray beam induced by bone crystals are determined for a range of acquisitions before three-dimensional reconstruction of bone architecture is performed. Morphometric parameters determined were trabecular bone volume/tissue volume, trabecular number, and trabecular thickness. The results show that ovariectomy has a dramatic effect on rat bone structure. Following treatment with the bone resorption inhibitor tiludronate, the morphometric parameters were significantly improved. The results obtained with three-dimensional microcomputed tomography were in agreement with observations made using classical techniques. Microcomputed tomography should prove useful for evaluating the antiresorptive effects of bisphosphon-ates on bone architecture and in allowing between-drug comparisons.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s007740050061
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    Paper (German National Licenses)
    Fulltext
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