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  • 1
    Electronic Resource
    Electronic Resource
    The gonadotropin response to synthetic gonadotropin releasing factor in patients with testicular cancer (1983)
    Springer
    Urological research 11 (1983), S. 69-73 
    Details
    ISSN: 1434-0879
    Keywords: Testicular cancer ; Pituitary gonadotropin release ; Synthetic gonatotropin releasing factor
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The response of LH and FSH to synthetic gonadotropin releasing factor (GRF) was investigated in 19 patients with malignant germ cell cancers of the testicle prior to radical orchiectomy. The study showed: 1. Patients with circulating beta-HCG presented with increased plasma levels of oestradiol. Base line FSH and response to GRF were significantly decreased. 2. In patients without detectable beta-HCG plasma concentrations of oestradiol and testosterone were within the normal ranges as compared to healthy age matched controls. Base line levels of FSH and LH were increased and an exaggerated response to GRF was observed. From the results of this study it can be concluded that hypergonadotropic dysfunction of pituitary-gonadal axis exists in patients with testicular cancer of germ cell origin. Beta-HCG production by tumour tissue results in hyperoestrogenism and interferes with the pituitary-gonadal axis in terms of inhibition of pituitary gonadotropin release.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00256950
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Pathological and morphometric assessment of testicular parameters in patients with metastatic prostate cancer following treatment with either the antiandrogen Casodex (ZM176,334) or bilateral orchidectomy (1994)
    Springer
    Urological research 22 (1994), S. 191-195 
    Details
    ISSN: 1434-0879
    Keywords: Casodex (ZM176.334) ; Orchidectomy ; Prostate cancer ; Testis ; Histopathology ; Morphometry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Casodex is an orally active non-steroidal antiandrogen that is highly selective for androgen receptors in animals and man. It is indicated for the non-surgical treatment of advanced prostate cancer in man. The present open controlled study in 13 Casodex-treated and 21 orchidectomy-alone (control) patients addressed the hypothesis that chronic administration of antiandrogens will result in Leydig cell hyperplasia as a result of feedback inhibition of the pituitary resulting in increased luteinising hormone (LH) stimulation of Leydig cells. Although Casodex has been shown to produce a moderate rise in circulating plasma testosterone concentration on chronic treatment in prostate cancer patients, a controlled histopathological and morphometric assessment of the testis following orchidectomy in relapsed Casodex patients showed no effect on Leydig cell populations compared with an orchidectomy alone (control) group. No evidence for induction of Leydig cell hypertrophy or hyperplasia as a result of chronic oral administration of 50 mg Casodex daily was obtained in this study.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00571849
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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