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Thyroid-specific gene expression

Damante, G. ; Di Lauro, R.

Amsterdam : Elsevier

Biochimica et Biophysica Acta (BBA)/Gene Structure and Expression 1218 (1994), S. 255-266

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ISSN: 0167-4781

Keywords: Gene expression ; TFC-specific protein ; Thyroid follicular cell ; Thyroid-specific transcription factor

Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002

Topics: Biology , Chemistry and Pharmacology , Medicine , Physics

Type of Medium: Electronic Resource

URL: http://linkinghub.elsevier.com/retrieve/pii/0167-4781(94)90176-7

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Structural study of rat thyroid transcription factor 1 homeodomain (TTF-1 HD) by nuclear magnetic resonance

Viglino, P. ; Fogolari, F. ; Formisano, S. ; [et al.]

Amsterdam : Elsevier

FEBS Letters 336 (1993), S. 397-402

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ISSN: 0014-5793

Keywords: Homeodomain ; Protein NMR ; Thyroid transcription factor 1 (TTF-1)

Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002

Topics: Biology , Chemistry and Pharmacology , Physics

Type of Medium: Electronic Resource

URL: http://linkinghub.elsevier.com/retrieve/pii/0014-5793(93)80845-L

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Analysis of the conformation and stability of rat TTF-1 homeodomain by circular dichroism

Damante, G. ; Tella, G. ; Leonardi, A. ; [et al.]

Amsterdam : Elsevier

FEBS Letters 354 (1994), S. 293-296

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ISSN: 0014-5793

Keywords: Circular dichroism ; DNA binding ; Homeodomain ; Protein structure ; Transcription factor ; α-Helix

Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002

Topics: Biology , Chemistry and Pharmacology , Physics

Type of Medium: Electronic Resource

URL: http://linkinghub.elsevier.com/retrieve/pii/0014-5793(94)01145-1

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Effect of intensive glycaemic control on fibrinogen plasma concentrations in patients with Type II diabetes mellitus. Relation with β-fibrinogen genotype (1998)

Ceriello, A. ; Mercuri, F. ; Fabbro, D. ; [et al.]

Springer

Diabetologia 41 (1998), S. 1270-1273

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ISSN: 1432-0428

Keywords: Keywords Fibrinogen ; β-fibrinogen genotype ; hyperglycaemia ; metabolic control ; gene-enviroment interaction.

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Summary Recent studies show that in diabetic subjects an increase of plasma fibrinogen concentration is associated with a high risk of cardiovascular complications. Environmental and genetic factors contribute to the plasma fibrinogen concentration. Several studies indicate a relation between the polymorphism in the 5 ′ region of the β-fibrinogen gene and plasma protein concentrations and in diabetes the possible influence of hyperglycaemia on fibrinogen is still debated. In this study we investigated these relations. Hind III polymorphism was evaluated by a polymerase chain reaction-technique. On the basis of the observed allelic combination of fibrinogen β-gene polymorphism and the existence of poor metabolic control (glycated haemoglobin ≥ 7.5 %), 50 Type II diabetic patients were selected. They were divided into three groups according to their β-gene polymorphism (α1α1: n = 20, α1α2: n = 15, α2α2: n = 15) and then intensive insulin therapy was started. After 3 months of intensive treatment, the improvement in glycaemic control was equivalent, in terms of glycated haemoglobin, in all the three groups. A fibrinogen reduction was observed in α1α2 and α2α2 but not in α1α1 subjects. These results underline a possible relation between fibrinogen genotypes and glycaemic control in determining plasma fibrinogen concentrations in diabetic patients. [Diabetologia (1998) 41: 1270–1273]

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/s001250051064

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