ISSN:
1433-8580
Keywords:
Phospholipid renin preinhibitor
;
Conversion to lysophospholipid renin inhibitor
;
Human plasma
;
Human kidney homogenate
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary In order to verify the possibility than human plasma and kidney can activate a renin preinhibitor (Phospholipid) into inhibitor (lysophospholipid), constant quantities of preinhibitor were added to plasma and kidney homogenate. Addition of preinhibitor to plasma did not modify the quantity of Angiotensin I that developed. On the other hand, addition of preinhibitor to crude kidney homogenate, followed by incubation with human angiotensinogen, caused a significant fall in the quantity of Angiotensin I generated. While plasma is deficient in the specific enzyme delegated to the transformation of preinhibitor into inhibitor, it appears that this enzyme is present in the kidney.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01852632
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