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  • Hydrophobic parameter  (2)
  • Pravastatin  (2)
  • [abr] 4-diene-3,20-dione  (2)
  • [abr] Dexamethasone  (2)
  • 1
    Electronic Resource
    Electronic Resource
    Effects of ACTH, metopirone and dexamethasone on maternal urinary steroid excretion in late pregnancy
    Amsterdam : Elsevier
    Steroids 15 (1970), S. 267-274 
    Details
    ISSN: 0039-128X
    Keywords: [abr] 17α,21-trihydroxypregn-1 ; [abr] 2-methyl-1,2 ; [abr] 4-diene-3,20-dione ; [abr] 9α-fluoro-16α-methyl-11β ; [abr] Dexamethasone ; [abr] bis-3-pyridyl-1-propanone ; [abr] metopirone or metyrapone
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/S0039-128X(70)80039-3
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Effects of ACTH, metopirone and dexamethasone on maternal urinary steroid excretion in late pregnancy
    Amsterdam : Elsevier
    Steroids 15 (1970), S. 267-274 
    Details
    ISSN: 0039-128X
    Keywords: [abr] 17α,21-trihydroxypregn-1 ; [abr] 2-methyl-1,2 ; [abr] 4-diene-3,20-dione ; [abr] 9α-fluoro-16α-methyl-11β ; [abr] Dexamethasone ; [abr] bis-3-pyridyl-1-propanone ; [abr] metopirone or metyrapone
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/S0039-128X(70)80039-3
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Effects of pravastatin on plasma and urinary mevalonate concentrations in subjects with familial hypercholesterolaemia: a comparison of morning and evening administration (1996)
    Springer
    European journal of clinical pharmacology 49 (1996), S. 361-364 
    Details
    ISSN: 1432-1041
    Keywords: Hypercholesterolaemia ; Pravastatin ; Mevalonate ; cholesterol synthesis ; circadian rhythm
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Abstract In order to determine whether there is a difference in the effect of the hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor pravastatin on cholesterol synthesis between the morning and the evening, we studied the 24-h profile of mevalonate in plasma and urine in 11 subjects with heterozygous familial hypercholesterolaemia. In study 1, eight subjects with familial hypercholesterolaemia took pravastatin (20 mg) once in the morning, and another 20-mg dose in the evening after a 1-week wash-out period. In study 2, five subjects with familial hypercholesterolaemia took pravastatin (20 mg per day) in the morning on 3 consecutive days and on 3 days in the evening after a 1 day wash-out. Plasma mevalonate concentrations were reduced at 9 h and 5 h after pravastatin administration in the morning and the evening, respectively. Urinary mevalonate excretion was significantly reduced at 4–8 h after pravastatin administration in the morning (51 vs 19 nmol · h−1) and at 4–16 h after pravastatin administration in the evening (56 vs 27 nmol · h−1). Daily urinary mevalonate excretion was equally and significantly reduced by pravastatin in the morning or evening. In conclusion, we found that morning and evening administration of pravastatin caused equal reductions in plasma and urinary mevalonate concentrations.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00203778
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    Effects of pravastatin on plasma and urinary mevalonate concentrations in subjects with familial hypercholesterolaemia: a comparison of morning and evening administration (1996)
    Springer
    European journal of clinical pharmacology 49 (1996), S. 361-364 
    Details
    ISSN: 1432-1041
    Keywords: Key words Hypercholesterolaemia ; Pravastatin ; Mevalonate; cholesterol synthesis ; circadian rhythm
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Abstract In order to determine whether there is a difference in the effect of the hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor pravastatin on cholesterol synthesis between the morning and the evening, we studied the 24-h profile of mevalonate in plasma and urine in 11 subjects with heterozygous familial hypercholesterolaemia. In study 1, eight subjects with familial hypercholesterolaemia took pravastatin (20 mg) once in the morning, and another 20-mg dose in the evening after a 1-week wash-out period. In study 2, five subjects with familial hypercholesterolaemia took pravastatin (20 mg per day) in the morning on 3 consecutive days and on 3 days in the evening after a 1 day wash-out. Plasma mevalonate concentrations were reduced at 9 h and 5 h after pravastatin administration in the morning and the evening, respectively. Urinary mevalonate excretion was significantly reduced at 4–8 h after pravastatin administration in the morning (51 vs 19 nmol ⋅h−1) and at 4–16 h after pravastatin administration in the evening (56 vs 27 nmol ⋅h−1). Daily urinary mevalonate excretion was equally and significantly reduced by pravastatin in the morning or evening. In conclusion, we found that morning and evening administration of pravastatin caused equal reductions in plasma and urinary mevalonate concentrations.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002280050032
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 5
    Electronic Resource
    Electronic Resource
    Evaluation of solute hydrophobicity by reversed-phase high performance liquid chromatography using aqueous binary mobile phases (1990)
    Springer
    Chromatographia 29 (1990), S. 275-288 
    Details
    ISSN: 1612-1112
    Keywords: Column liquid chromatography ; Hydrophobic parameter ; Capacity factor variation ; Organic modifier concentration ; Displacement model
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary The dependence of the capacity factor (k′) on the concentration of the organic modifier (D) in the aqueous binary mobile phase in reversed-phase high-performance liquid chromatography has been investigated to evaluate the hydrophobicity of the solute molecule. The r-values, defined as the slope of log k′ vs. log(1/D) plots, were measured for various solutes and related to the non-polar surface area and the partition coefficients. The r-value was found to be a good indication of solute hydrophobicity. Detailed investigation of the results allowed to consider statistically the molecular posture of the solute adsorbed onto the stationary alkyl ligand.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02317918
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    Retention characteristics of octadecylsilyl silica, trimethylsilyl silica and phenyldimethylsilyl silica in reversed-phase liquid chromatography (1990)
    Springer
    Chromatographia 30 (1990), S. 99-104 
    Details
    ISSN: 1612-1112
    Keywords: Column liquid chromatography ; Reversed stationary phases ; Hydrophobic parameter ; Water/methanol eluent mixtures
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary The hydrophobic retention characteristics of stationary ligands for reversed-phase high-performance liquid chromatography have been evaluated from the slope (r-value) of the plots relating the capacity factors (log k′) of selected aliphatic and aromatic compounds with the reciprocal of methanol concentration (log (1/[MeOH])) in aqueous mobile phase. Octadecylsilyl (ODS), trimethylsilyl (TMS) and phenyldimethylsilyl (phenyl) groups were selected as the stationary ligands bonded to silica support. On ODS or TMS silicas, unlike on phenyl silica, aliphatic compounds gave slightly larger r-values than aromatic compounds, indicating that the shape of the ligand recognizes the hydrophobic surfaces of aliphatic and aromatic solute molecules. On TMS and phenyl silicas, the degree of solute hydrophobicity contributing to its retention is about 90% and 85% of that on ODS silica, respectively. On the other hand, on TMS and phenyl silicas, the polar functional group on the solute molecule brought about a smaller decrease in retention than on ODS silica.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02270457
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    Paper (German National Licenses)
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