ISSN:
1432-1238
Keywords:
Cyanide
;
Hydroxocobalamin
;
Cobalt edetate
;
Catecholamines
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Objectives The hemodynamic effects of two cyanide antidotes, hydroxocobalamin and cobalt edetate were compared. Design This experimental study was performed in chronically instrumented conscious dogs and at equipotent cyanide antidotal doses (hydroxocobalamin 70 mg·kg−1; cobalt edetate 10.5 mg·kg−1). Results Peak plasma cobalt concentrations did not differ in the two groups (412±183 vs 400±160 μmol·1−1). Hydroxocobalamin induced a slight increase in mean arterial pressure (+17±9%,p〈0.05) and systemic resistance (+19±15%,p〈0.05). In contrast, cobalt edetate induced an increase in heart rate (+78±33%,p〈0.05), in cardiac output (+63±39%,p〈0.05), and in maximum rise of left ventricular pressure (+33±15%,p〈0.05), did not modify mean arterial pressure, and decreased systemic resistance (−36±15%,p〈0.05). These hemodynamic effects were associated with an increase in plasma catecholamine concentrations (epinephrine: 2524±3025 vs. 58±37 pg·ml−1,p〈0.05; norepinephrine: 1106±609 vs. 343±146 pg·ml−1,p〈0.05), which in contrast remained unchanged after hydroxocobalamin administration. Cobalt edetate also induced an increase in blood glucose concentrations (9.9±1.9 vs. 6.1±1.2 mmol·l−1,p〈0.05) and a moderate metabolic acidosis, whereas hydroxocobalamin did not. After adrenergic (α1,β) and cholinergic receptor blockade, cobalt edetate did not modify heart rate and various indices of cardiac function, suggesting that it has no direct cardiac effects. Conclusion Considering its lack of hemodynamically relevant effects, these results indicate that hydroxocobalamin is potentially a safer cyanide antidote than cobalt edetate.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01709274
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