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  • 1
    Electronic Resource
    Electronic Resource
    Reference data for ambulatory blood pressure monitoring: What results are equivalent to the established limits of office blood pressure? (1990)
    Springer
    Journal of molecular medicine 68 (1990), S. 723-727 
    Details
    ISSN: 1432-1440
    Keywords: Ambulatory blood pressure monitoring (ABPM) ; Normal values ; Office blood pressure ; Hypertension ; Reference data
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In 1039 subjects ambulatory blood pressure monitoring was performed to define threshold values, which are equivalent to the established limits of the office blood pressure. Mean values and proportions of elevated single readings were correlated to office blood pressure by regression analyses. To avoid impact of varying sleeping periods on 24 h blood pressure, only daytime readings were considered. Correlations between average daytime blood pressure and office blood pressure were linear: Mean daytime values of 135 mmHg (systolic) and of 84 mmHg (diastolic) were equivalent to the casual blood pressure limits of 140 mmHg and 90 mmHg. Correlations between percentages of elevated single readings and office blood pressure were nonlinear: Proportions of 25% systolic readings 〉 140 mmHg and of 17% diastolic readings 〉 90 mmHg were equivalent to casual blood pressure limits of 140 mmHg and 90 mmHg. On the basis of the regression equations, any result of ambulatory blood pressure recording during daytime can now be evaluated in terms of the established standards of office blood pressure.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01647580
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  • 2
    Electronic Resource
    Electronic Resource
    Morgendlicher Blutdruckanstieg: vor oder nach dem Aufwachen? (1990)
    Springer
    Journal of molecular medicine 68 (1990), S. 320-323 
    Details
    ISSN: 1432-1440
    Keywords: Blood pressure ; Hypertension ; Sleep ; Waking up ; Antihypertensive therapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The coincidence of the circadian peak of cardiovascular events with the morning blood pressure rise suggests causal connections. Rapidly acting antihypertensives taken before getting up may attenuate the increase early enough, if the onset does not occur before awakening. In 111 normotensives and in 109 subjects with untreated essential hypertension ambulatory blood pressure monitoring was performed to study whether the onset of the blood pressure rise occurs before or after waking up. The individual 24 h blood pressure profiles obtained by intermittent readings at intervals of 15 minutes were synchronized by the time of waking up. The resulting blood pressure curves showed no substantial blood pressure rise during sleep, but steep increases after awakening: Within the first hour after waking up blood pressure increased from 107.3+11.4/62.3±9.6 mm Hg (mean+sd) to 121.4±16.0/75.3+12.6 mm Hg in normotension and from 124.7+16.0/72.7+12.2 mm Hg to 140.3+17.2/84.5+13.3 mm Hg in hypertension. The velocity of this increase was dependent on the lag between waking up and getting up. There was no phase difference between early morning blood pressure and heart rate rises. Thus to attenuate the morning blood pressure increase, rapidly acting drugs after awakening may be considered instead of long acting antihypertensives administered prior to sleep.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01649023
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Clinical experience with dual-acting drugs in hypertension (1992)
    Springer
    Journal of molecular medicine 70 (1992), S. S39 
    Details
    ISSN: 1432-1440
    Keywords: Carvedilol ; Celiprolol ; Labetalol ; Dual-acting drugs ; Hypertension
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary There are now several antihypertensive agents with dual actions. Among these, labetalol has been studied most extensively. The drug has a place in the chronic treatment of hypertension and in the therapy of hypertensive emergencies. Carvedilol, now available in Germany, has been shown to be effective in different forms of hypertension. Celiprolol binds to beta 1- and beta 2-receptors. This drug also binds to alpha 2-receptors. It is not clear, at present, whether or not this binding property contributes to its antihypertensive effect.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00207610
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  • 4
    Electronic Resource
    Electronic Resource
    Plasma dopamine-β-hydroxylase activity and the pressor effect of dopamine infusion in man (1976)
    Springer
    European journal of clinical pharmacology 10 (1976), S. 197-200 
    Details
    ISSN: 1432-1041
    Keywords: Dopamine-β-hydroxylase ; dopamine infusion ; blood pressure ; plasma ; man ; inter-individual variation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary In order to study the function of dopamine-β-hydroxylase (DBH) in human plasma, dopamine, its natural substrate, was infused intravenously in 22 healthy volunteers. Their plasma DBH activities showed great interindividual variations (31–301 units/ml). The infusion rates of dopamine required to increase systolic blood pressure (BP) by 30 mm Hg differed considerably between the subjects, and ranged from 3,0 to 11,6 µg/kg/min. No correlation could be shown between the various dopamine doses and individual plasma levels of DBH. It was concluded, therefore, that plasma DBH in the blood stream was enzymatically inactive. Experiments with human plasma DBH in vitro also support this interpretation. Consequently, interindividual differences in the effects on BP during dopamine infusion cannot be due to pressor effects of noradrenaline synthesized by plasma DBH.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00558329
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  • 5
    Electronic Resource
    Electronic Resource
    The influence of antituberculosis drugs on the plasma level of verapamil (1987)
    Springer
    European journal of clinical pharmacology 32 (1987), S. 107-109 
    Details
    ISSN: 1432-1041
    Keywords: verapamil ; rifampicin ; calcium antagonist ; drug interactions ; ethambutol ; isoniazid
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The influence of antituberculosis drugs on the plasma level of verapamil was studied after its oral and intravenous administration. Six patients who had been treated for at least 6 months with a combination of rifampicin, ethambutol and isoniazid received a single oral dose of 40 mg verapamil. As compared to untreated subjects, the antituberculosis drugs greatly reduced the bioavailability of the calcium antagonist. Studies in patients in whom treatment with ethambutol and isoniazid had been discontinued revealed that the effect was due to rifampicin. The drugs for tuberculosis had no influence on the plasma level of verapamil when it was given intravenously. The findings can be explained by the induction of verapamil metabolizing liver enzymes in patients treated with rifampicin.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00609969
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    Influence of dobutamine and dopamine on hemodynamics and plasma concentrations of noradrenaline and renin in patients with low cardiac output following acute myocardial infarction (1982)
    Springer
    European journal of clinical pharmacology 21 (1982), S. 355-356 
    Details
    ISSN: 1432-1041
    Keywords: dopamine infusion ; plasma noradrenaline
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00637626
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  • 7
    Electronic Resource
    Electronic Resource
    Pharmacokinetics of verapamil in patients with renal failure (1985)
    Springer
    European journal of clinical pharmacology 28 (1985), S. 405-410 
    Details
    ISSN: 1432-1041
    Keywords: verapamil ; renal failure ; norverapamil ; pharmacokinetics ; haemodialysis ; ECG ; blood pressure ; heart rate
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The pharmacokinetics of verapamil was studied in patients with end-stage chronic renal failure and in normal subjects after i.v. injection of 3 mg and a single oral dose of 80 mg. Plasma levels of verapamil and its active metabolite norverapamil were measured by HPLC. After i.v. injection, the terminal phase half-life and total plasma clearance of verapamil in both groups were similar. Haemodialysis did not change the time course of plasma verapamil levels after i.v. administration. After a single oral dose, the plasma levels of verapamil and norverapamil in both groups of subjects were similar. Subsequently, normal volunteers and patients with renal failure were treated for 5 days with oral verapamil 80 mg t.d.s. There was no difference between the 2 groups of subjects in the trough and peak levels of verapamil or of norverapamil. Intravenous and oral administration of the calcium channel blocking agent had similar effects on blood pressure, heart rate and the PR-interval in the electrocardiogram in both groups. The study demonstrated that the disposition of verapamil was similar in normal subjects and in patients with renal failure.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00544358
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  • 8
    Electronic Resource
    Electronic Resource
    The influence of chronic treatment with verapamil on plasma atrial natriuretic peptide levels in young and elderly hypertensive patients (1990)
    Springer
    European journal of clinical pharmacology 39 (1990), S. S39 
    Details
    ISSN: 1432-1041
    Keywords: ANP ; verapamil ; hypertension ; age
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary In a double-blind, placebo-controlled crossover study, the plasma atrial natriuretic peptide (ANP) levels of nine young and ten elderly hypertensive patients were compared after placebo and after treatment with 120 mg verapamil given three times daily over 4 weeks. During placebo, plasma ANP levels proved to be higher in elderly patients than in young subjects. Chronic treatment with verapamil induced a rise in ANP levels in both young and elderly patients with hypertension.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01409206
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