ISSN:
1432-2072
Keywords:
Marijuana
;
Cannabis
;
Cannabinoids
;
Δ 9-tetrahydrocannabinol
;
THC
;
Brain stimulation reward
;
Intracranial self-stimulation
;
ICSS
;
Reinforcement
;
Medial forebrain bundle
;
Rat
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract The present experiment explored whetherΔ 9-tetrahydrocannabinol (Δ 9-THC), the psychoactive ingredient in marijuana, shares with other drugs of abuse the ability to facilitate brain stimulation reward acutely, as measured by clectrical intracranial self-stimulation (ICSS). Laboratory rats were implanted with stimulation electrodes in the medial forebrain bundle, and trained to stable performance on a self-titrating threshold ICSS paradigm.Δ 9-THC, at a dose believed pharmacologically relevant to moderate human use of marijuana, acutely lowered ICSS thresholds, suggesting that marijuana acts on similar CNS hedonic systems to most other drugs of abuse.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02431546
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