ISSN:
1432-2072
Schlagwort(e):
Marijuana
;
Cannabis
;
Cannabinoids
;
Δ 9-tetrahydrocannabinol
;
THC
;
Brain stimulation reward
;
Intracranial self-stimulation
;
ICSS
;
Reinforcement
;
Medial forebrain bundle
;
Rat
Quelle:
Springer Online Journal Archives 1860-2000
Thema:
Medizin
Notizen:
Abstract The present experiment explored whetherΔ 9-tetrahydrocannabinol (Δ 9-THC), the psychoactive ingredient in marijuana, shares with other drugs of abuse the ability to facilitate brain stimulation reward acutely, as measured by clectrical intracranial self-stimulation (ICSS). Laboratory rats were implanted with stimulation electrodes in the medial forebrain bundle, and trained to stable performance on a self-titrating threshold ICSS paradigm.Δ 9-THC, at a dose believed pharmacologically relevant to moderate human use of marijuana, acutely lowered ICSS thresholds, suggesting that marijuana acts on similar CNS hedonic systems to most other drugs of abuse.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1007/BF02431546
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