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  • 1
    ISSN: 1432-1440
    Keywords: Iodine-induced hyperthyroidism ; Toxic adenoma ; Graves' disease ; Xenotransplanted thyroid tissue ; Athymic nude mice ; 131I kinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The effect of different doses of continuous iodine infusion on xenotransplanted human thyroid tissue from toxic adenoma, and Graves' disease was examined using131I scintigraphy in athymic nude mice. In spite of pretreatment with high iodine doses (1.25 µg or 12.5 µg131I per day via i.p. implanted minipumps, Alzet 2002), the radioactivity localized in the transplanted tissue of toxic adenoma was more than 50% of the radioactivity in the transplants of the controls without iodine pretreatment 2 h after131I injection, which was not a significant difference. Moreover, after high iodine treatment the131I turnover rate in the thyroid transplants of toxic adenoma increased significantly. A tendency to an increased turnover rate was already observed with the lower dose. In contrast to that the transplants of Graves' disease tissue and mouse thyroids responded to high iodine treatment with a significant decrease in131I retention. Serum of an untreated patient with active Graves' disease or injections of TSH increased131I retention and the131I turnover rate in the transplanted tissue of Graves' disease significantly (P〈0.01). Iodine turnover was still increased after high iodine treatment. These results again show that thyroid tissue of toxic adenoma remains hyperfunctional after transplantation to athymic nude mice in contrast to thyroid tissue of Graves' disease which loses all signs of hyperfunction, when no exogenous stimulator is administered. In addition, these data clearly demonstrate, for the first time under in vivo conditions, that high iodine doses accelerate iodine turnover and thus presumably hyperfunction of human toxic adenoma in a dose-dependent manner as well as of the activated thyroid in Graves' disease.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Langenbeck's archives of surgery 369 (1986), S. 726-726 
    ISSN: 1435-2451
    Keywords: Predictive criteria ; Splenectomy ; Idiopathic thrombocytopenic purpura ; M. Werlhof ; Splenektomie ; Erfolgsaussichten
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die Auswertung von 98 Splenektomien wegen M. Werlhof und die klinische Nachuntersuchung von 51 Patienten ergab, daß sich der Remissionserfolg anhand folgender Parameter abschätzen läßt: Liegen die Thrombocyten bei Diagnosestellung 〉 10,000/mm3 oder steigen unter Corticoidtherapie auf 〉 10,000/mm3 besser 〉 50,000/mm3 an, sind vor allem bei Milzvergrößerung die Erfolgsaussichten der Splenektomie sehr gut. Steigen die Thrombocyten 2 Wochen postoperativ 〉 100,000/mm3, entwickeln 94,1% der Patienten eine dauerhafte Vollremission. Die Frühergebnisse 2 Wochen postoperativ und die Nachuntersuchung 3 Monate bis 6 Jahre nach Splenektomie ergab eine fast identische Quote von über 80% dauerhaften Vollremissionen und über 12% Teilremission.
    Notes: Summary Reinvestigation after 3 months–6 years of 51 of 98 patients who underwent splenectomy because of Werhof's disease revealed excellent remission rates when the number of thrombocytes was 〉 10,000/mm3 at the time of diagnosis, when there was an increase to 〉 10,000/mm3, or better still, when 〉 50,000/mm3 was achieved by corticosteroid therapy, especially when the spleen was enlarged. An increase in the thrombocytecount to 〉 100,000/mm3 2 weeks after splenectomy was associated with a complete remission in 94.1%. The early remission rates (2 weeks postoperatively) and the late results (after 3 months–6 years) were nearly identical: in more than 80% of cases, complete remissions, and in over 12%, partial remissions could be observed.
    Type of Medium: Electronic Resource
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