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  • 1
    ISSN: 1432-1440
    Keywords: Iodine-induced hyperthyroidism ; Toxic adenoma ; Graves' disease ; Xenotransplanted thyroid tissue ; Athymic nude mice ; 131I kinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The effect of different doses of continuous iodine infusion on xenotransplanted human thyroid tissue from toxic adenoma, and Graves' disease was examined using131I scintigraphy in athymic nude mice. In spite of pretreatment with high iodine doses (1.25 µg or 12.5 µg131I per day via i.p. implanted minipumps, Alzet 2002), the radioactivity localized in the transplanted tissue of toxic adenoma was more than 50% of the radioactivity in the transplants of the controls without iodine pretreatment 2 h after131I injection, which was not a significant difference. Moreover, after high iodine treatment the131I turnover rate in the thyroid transplants of toxic adenoma increased significantly. A tendency to an increased turnover rate was already observed with the lower dose. In contrast to that the transplants of Graves' disease tissue and mouse thyroids responded to high iodine treatment with a significant decrease in131I retention. Serum of an untreated patient with active Graves' disease or injections of TSH increased131I retention and the131I turnover rate in the transplanted tissue of Graves' disease significantly (P〈0.01). Iodine turnover was still increased after high iodine treatment. These results again show that thyroid tissue of toxic adenoma remains hyperfunctional after transplantation to athymic nude mice in contrast to thyroid tissue of Graves' disease which loses all signs of hyperfunction, when no exogenous stimulator is administered. In addition, these data clearly demonstrate, for the first time under in vivo conditions, that high iodine doses accelerate iodine turnover and thus presumably hyperfunction of human toxic adenoma in a dose-dependent manner as well as of the activated thyroid in Graves' disease.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Virchows Archiv 387 (1980), S. 117-123 
    ISSN: 1432-2307
    Keywords: Intravascular bronchioloalveolar tumour ; Histological findings ; Lymphatic spread
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A 56-year-old lady with distinct clinical symptoms was found to have an intravascular bronchioloalveolar tumour. The aetiology and pathogenesis of this disease are unknown; both a bronchoalveolar and a vascular origin of the tumour are discussed in the literature. For the first time, lymphatic spread of tumour to the lymphatic nodes of the hili of the lungs was encountered.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Virchows Archiv 383 (1979), S. 207-216 
    ISSN: 1432-2307
    Keywords: Primary sarcoma of pulmonary artery ; Light-electron and immunofluorescence microscopy findings ; Myointimal cells
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A 25-year-old man with chest pain and shortness of breath was found to have a primary sarcoma of the pulmonary artery. On light- and electronmicroscopy and immunofluorescence microscopy the lesion was found to be composed of cells of smooth muscle origin. It was diagnosed as leiomyosarcoma. The cross and microscopic features of the tumor are described and the morphologic characteristics of previously reported vascular sarcomas are briefly reviewed.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1432-1904
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1435-2451
    Keywords: Pancreatic duct ; Occlusion ; Chronic pancreatitis ; Pankreasgangocclusion ; Chronische Pankreatitis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Es bestehen widersprüchliche Aussagen bezüglich des Langzeitverhaltens des endokrinen Pancreas nach Ethibloc-Gangocclusion. In dieser klinischen Beobachtung überprüften wir die Langerhanschen Inseln 20 Monate nach Occlusion, da die junge Patientin wegen erneuter Schmerzen duodenopankreatektomiert wurde. Neben schweren exokrinen, fibrotischen Umbauvorgängen zeigten sich deutliche, fortschreitende endokrine Beeintrachtigungen insbesondere bei den Beta-Zellen. Besonders betroffen waren die Ultrastrukturen. Wir glauben daher, daß die Pankreasgangocclusion mit Ethiobloc in Kombination mit der Pankreassegmenttransplantation zu risikoreich ist. Eine erneute endocrine Pankreasinsuffizienz wurde these zumeist jugendlichen Patienten in besonderem Maß belasten.
    Notes: Summary There have been contradictory statements on the long-term behaviour of the endocrine pancreas following prolamin duct occlusion. In this clinical observation, we had a chance to test the islets of Langerhans immunohistochemically and ultra-structurally 20 months post-occlusion. Recurrent pain in combination with chronic pancreatitis forced us to perform a duodenopancreatectomy. Besides severe exocrine fibrotic alterations, distinctly progressive signs of degeneration in the beta-cells (chiefly ultrastructurally) were demonstrated. Thus, we believe that pancreatic duct occlusion by prolamin, in combination with pancreas transplantation, is too dangerous, as recurrent endocrine insufficiency would be especially unfavourable in these patients, who are mostly young.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Langenbeck's archives of surgery 361 (1983), S. 916-916 
    ISSN: 1435-2451
    Keywords: Islets of Langerhans ; Pancreatic duct ; Prolamin ; Langerhans'sche Inseln ; Pankreasgangocclusion ; Prolamin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Ziel dieser klinischen Beobachtung ist zu überprüfen, ob nach Pankreasgangocclusion mit Ethibloc unseren tierexperimentellen Befunden vergleichbare histomorphologische, immunohistochemische sowie ultrastrukturelle Veränderungen nachweisbar sind. Tatsächlich finden sich bei einer 31 Jahre alten Patientin 6 Monate nach Pankreasgangocclusion deutliche Zeichen cellulärer und ultrastruktureller Schädigungen innerhalb der Langerhans'schen Inseln. Dies deutet auf eine langfristige Gefährdung der Beta-Zellen und somit des Glucosestoffwechsels hin. Möglicherweise sind andere Occlusionssubstanzen geeigneter.
    Notes: Summary Aim of the clinical observation was to test whether, following pancreatic duct obstruction with Ethibloc, histomorphological alterations within the islets of Langerhans can be proved. — As in our experimental data, 6 months after sclerotherapy we can demonstrate distinct damage within the endocrine pancreas of a 31-year-old women. These findings can be shown histomorphologically, by immunohistochemical techniques and by electron microscopy. The beta-cell system appears endangered on a long-term basis. Different occlusion substances might be more suitable.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Langenbeck's archives of surgery 366 (1985), S. 297-301 
    ISSN: 1435-2451
    Keywords: Postoperative Ileus ; Postoperative peritonitis ; Therapy ; Postoperativer Ileus ; Postoperative Peritonitis ; Therapie
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Bei jedem postoperativen Frühileus initialer Versuch der Darmdekompression durch endoskopisch plazierte Dfnndarmsonde (Erfolgsquote 80%). Bei eindeutiger mechanischer Behinderung oder diffuser Peritonitis Relaparotomie. - Bei anhaltender Atonie oder funktionellem Ileus konservative Therapie (Sonde, Substitutionstherapie, Peristaltica, evtl. Sympathicolyse mit nachfolgender Stimulation) und geduldige Beobachtung unter dem Auge des Erfahrenen. Bei lokaler Peritonitis Versuch der percutanen Punktion und Drainage, ggf. als vorbereitende Notfallmaßnahme für die spätere Operation. Cave Problempatienten!
    Notes: Summary In each case of postoperative ileus initial decompression of the intestine by an endoscopically placed tube is indicated (success rate 80%). With clear mechanical obstruction or diffuse peritonitis immediate relaparotomy is indicated. With prolonged gastrointestinal dilatation or paralytic ileus conservative therapy (tube-decompression, substitution of fluids and electrolytes, peristaltics, sympathicolysis with following stimulation) and close observation by an experienced surgeon is recommended. With local peritonitis (intraabdominal abscess) percutaneous puncture and drainage, sometimes just as a preliminary emergency procedure seems worthwhile.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Langenbeck's archives of surgery 366 (1985), S. 595-595 
    ISSN: 1435-2451
    Keywords: Thyroid carcinoma ; Hyperthyroidism ; Schilddrüsencarcinom ; Koincidenz bei Hyperthyreose
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Zwischen 1973 und 1982 wurden 1701 Schilddrüseneingriffe durchgeführt. 2% der 177 wegen diffuser Hyperthyreose und 3% der 184 wegen knotiger Hyperthyreose operativ behandelten Patienten hatten gleichzeitig ein Schilddrüsencarcinom. Histologisch waren alle 9 Carcinome vom papillären Typ. Das mittlere Lebensalter der Patienten mit Hyperthyreose und Carcinom lag bei 45–50 Jahren, mit einer Ausnahme handelte es sich um Frauen. Die Mehrzahl der Carcinome war größer als 1 cm und zeigte eine intra- oder extrathyreoidale T umorausbreitung. Zum Ausschluß bösartiger Erkrankungen sollte bei Hyperthyreosepatienten mit sonographisch verdächtigen Befunden die Indikation zur Operation großzügig gestellt werden.
    Notes: Summary Between 1973 and 1984, 1701 patients have been treated surgically because of thyroid diseases. Two percent of 177 patients with diffuse toxic goiter and 3% of 184 patients with toxic nodules had also developed a thyroid carcinoma. All nine carcinomas were histologically of the papillary type. The mean age of the patients was 45–50 years; 8 of them were women. Only in 3 patients were the tumors smaller than 1 cm in diameter, and most of the tumors showed local spreading. Patients with hyperthyroidism should be treated surgically to exclude thyroid carcinoma whenever lesions can be seen by ultrasonography that an suggestive of malignancy.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Langenbeck's archives of surgery 373 (1988), S. 243-247 
    ISSN: 1435-2451
    Keywords: Leiomyosarcoma of the pulmonary artery ; Clinical report of two new cases ; Review of the literature
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Primäre Sarkome der Arteria pulmonalis sind seltene Tumoren. In der Welt-literatur wird über insgesamt 81 Fälle berichtet. Davon sind 17% Leiomyosarkome. Die meisten dieser Tumoren werden nicht während des Lebens, sondern häufig zufällig bei der Autopsie entdeckt. Das primäre Leiomyosarkom der A. pulmonalis ist also ein ganz besonders seltener Tumor. Wir berichten über zwei klinische Fälle und geben einen Überblick über die Literatur.
    Notes: Summary Sarcoma of the pulmonary artery is a rare tumor. Only 81 cases are reported in the international literature. Leiomyosarcoma of the pulmonary artery is seen in 17% of these tumors. Most of them are not recognized during life but accidentally found at autopsy. So primary leiomyosarcoma of the pulmonary artery is a very rare tumor. We report about two new clinical cases and give a review of the literature.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    Langenbeck's archives of surgery 369 (1986), S. 726-726 
    ISSN: 1435-2451
    Keywords: Predictive criteria ; Splenectomy ; Idiopathic thrombocytopenic purpura ; M. Werlhof ; Splenektomie ; Erfolgsaussichten
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die Auswertung von 98 Splenektomien wegen M. Werlhof und die klinische Nachuntersuchung von 51 Patienten ergab, daß sich der Remissionserfolg anhand folgender Parameter abschätzen läßt: Liegen die Thrombocyten bei Diagnosestellung 〉 10,000/mm3 oder steigen unter Corticoidtherapie auf 〉 10,000/mm3 besser 〉 50,000/mm3 an, sind vor allem bei Milzvergrößerung die Erfolgsaussichten der Splenektomie sehr gut. Steigen die Thrombocyten 2 Wochen postoperativ 〉 100,000/mm3, entwickeln 94,1% der Patienten eine dauerhafte Vollremission. Die Frühergebnisse 2 Wochen postoperativ und die Nachuntersuchung 3 Monate bis 6 Jahre nach Splenektomie ergab eine fast identische Quote von über 80% dauerhaften Vollremissionen und über 12% Teilremission.
    Notes: Summary Reinvestigation after 3 months–6 years of 51 of 98 patients who underwent splenectomy because of Werhof's disease revealed excellent remission rates when the number of thrombocytes was 〉 10,000/mm3 at the time of diagnosis, when there was an increase to 〉 10,000/mm3, or better still, when 〉 50,000/mm3 was achieved by corticosteroid therapy, especially when the spleen was enlarged. An increase in the thrombocytecount to 〉 100,000/mm3 2 weeks after splenectomy was associated with a complete remission in 94.1%. The early remission rates (2 weeks postoperatively) and the late results (after 3 months–6 years) were nearly identical: in more than 80% of cases, complete remissions, and in over 12%, partial remissions could be observed.
    Type of Medium: Electronic Resource
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