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  • 1
    Electronic Resource
    Electronic Resource
    Imidazole has similar behavioural effects to yohimbine (1986)
    Springer
    Psychopharmacology 88 (1986), S. 58-62 
    Details
    ISSN: 1432-2072
    Keywords: Imidazole ; B-HT 920 ; Yohimbine ; Yawning-stretching behaviour ; Penile erection ; Dopamine ; Clonidine ; Adrenoceptors ; Chick ; Mouse ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A number of animal behavioural models were used to study the activity of imidazole (IMID) on the central nervous system. IMID antagonized in a dose-related fashion penile erections (PE) as well as stretching and yawning (SY) elicited in male rats by B-HT 920, an α2 and dopamine (DA) autoreceptor agonist. Inhibition of B-HT 920-induced PE and SY was also exhibited by haloperidol, a DA receptor blocker, and yohimbine, but not by prazosin, α2 and α1 receptor antagonists respectively. Moreover IMID behaved similarly to yohimbine in: 1) counteracting clonidine-induced hypothermia in mice; 2) antagonizing sedation and sleep induced by clonidine and B-HT 920 in chicks, while haloperidol was ineffective. When administered to sexually active rats before the copulatory test, IMID at low doses, significantly altered some aspects of mating, a result which is interpretable in terms of enhanced sexual arousal and resembling the aphrodisiac effect reported for yohimbine. The neurochemical mechanisms involved in these effects are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00310513
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Influence of cimetidine, ranitidine and imidazole on the behavioral effects of (±) N-n-propylnorapomorphine in male rats (1985)
    Springer
    Psychopharmacology 85 (1985), S. 197-200 
    Details
    ISSN: 1432-2072
    Keywords: Cimetidine ; Rantidine ; Imidazole ; (±) NPA ; Penile erections ; Stretching and yawning ; Stereotyped behaviour ; DA receptors ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Cimetidine injected IP 15 min before (±) N-n-propylnorapomorphine (NPA) antagonized in dose-dependent fashion the penile erections (PE) and stretching and yawning (SY) induced by this typical dopaminergic agonist in male rats. Ranitidine, which acts on H2 histamine receptors in much the same way as cimetidine despite its lack of an imidazole ring, failed to produce the same effect. On the other hand, imidazole itself was similar to cimetidine in antagonizing PE and SY induced by (±) NPA, whether injected IP or ICV. Neither imidazole nor cimetidine antagonized the stereotyped behaviour (SB) induced by (±) NPA. Indeed, imidazole reduced the latency of this response. A mechanism which may underly these effects is discussed, as well as the possible preclinical use of this test in animals.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00428413
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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