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  • 1
    Electronic Resource
    Electronic Resource
    The role of dopaminergic receptors in the behavioral effects induced by lisuride in male rats (1983)
    Springer
    Psychopharmacology 80 (1983), S. 38-42 
    Details
    ISSN: 1432-2072
    Keywords: Lisuride ; DA-receptors ; Penile erection ; Stretching and yawning ; Behavior ; Dopaminergic antagonists ; Methysergide ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Lisuride increased the incidence of stretching and yawning (SY) as well as of penile erection (PE) and elicited stereotyped behavior (SB), aggressive behavior and mounting in male rats, depending on the dose used. SY was prevented by two dopaminergic antagonists, haloperidol and sulpiride, but not by methysergide, a serotoninergic antagonist, while PE was antagonized by all three drugs. With regard to SB, aggressive behavior and mounting, all three were suppressed by haloperidol; sulpiride, while partially antagonizing aggressiveness, failed to affect SB and mounting; methysergide did not significantly influence any of the three. This suggests that lisuride principally affects the dopaminergic system. Although further detailed studies are required to elucidate which type of the complex population of DA-receptors is involved in each kind of behavior, we suggest that SY at least is due to the activation by lisuride of presynaptic DA-receptors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00427492
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Influence of cimetidine, ranitidine and imidazole on the behavioral effects of (±) N-n-propylnorapomorphine in male rats (1985)
    Springer
    Psychopharmacology 85 (1985), S. 197-200 
    Details
    ISSN: 1432-2072
    Keywords: Cimetidine ; Rantidine ; Imidazole ; (±) NPA ; Penile erections ; Stretching and yawning ; Stereotyped behaviour ; DA receptors ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Cimetidine injected IP 15 min before (±) N-n-propylnorapomorphine (NPA) antagonized in dose-dependent fashion the penile erections (PE) and stretching and yawning (SY) induced by this typical dopaminergic agonist in male rats. Ranitidine, which acts on H2 histamine receptors in much the same way as cimetidine despite its lack of an imidazole ring, failed to produce the same effect. On the other hand, imidazole itself was similar to cimetidine in antagonizing PE and SY induced by (±) NPA, whether injected IP or ICV. Neither imidazole nor cimetidine antagonized the stereotyped behaviour (SB) induced by (±) NPA. Indeed, imidazole reduced the latency of this response. A mechanism which may underly these effects is discussed, as well as the possible preclinical use of this test in animals.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00428413
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Imidazole has similar behavioural effects to yohimbine (1986)
    Springer
    Psychopharmacology 88 (1986), S. 58-62 
    Details
    ISSN: 1432-2072
    Keywords: Imidazole ; B-HT 920 ; Yohimbine ; Yawning-stretching behaviour ; Penile erection ; Dopamine ; Clonidine ; Adrenoceptors ; Chick ; Mouse ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A number of animal behavioural models were used to study the activity of imidazole (IMID) on the central nervous system. IMID antagonized in a dose-related fashion penile erections (PE) as well as stretching and yawning (SY) elicited in male rats by B-HT 920, an α2 and dopamine (DA) autoreceptor agonist. Inhibition of B-HT 920-induced PE and SY was also exhibited by haloperidol, a DA receptor blocker, and yohimbine, but not by prazosin, α2 and α1 receptor antagonists respectively. Moreover IMID behaved similarly to yohimbine in: 1) counteracting clonidine-induced hypothermia in mice; 2) antagonizing sedation and sleep induced by clonidine and B-HT 920 in chicks, while haloperidol was ineffective. When administered to sexually active rats before the copulatory test, IMID at low doses, significantly altered some aspects of mating, a result which is interpretable in terms of enhanced sexual arousal and resembling the aphrodisiac effect reported for yohimbine. The neurochemical mechanisms involved in these effects are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00310513
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Influence of lisuride on morphine withdrawal signs in the rat: A dopamine-mimetic effect (1982)
    Springer
    Psychopharmacology 78 (1982), S. 326-330 
    Details
    ISSN: 1432-2072
    Keywords: Morphine withdrawal ; Dopamine ; Lisuride ; N-n-propylnorapomorphine ; Haloperidol ; Sulpiride ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The influence of lisuride on naloxone-induced withdrawal signs (wet shakes, escape attempts) was studied in morphine-dependent rats. Lisuride, injected IP at doses of 12.5 and 25 μg/kg, inhibited wet shakes while not significantly altering escape attempts induced by naloxone (4 mg/kg IP). At higher doses (50 and 100 μg/kg IP), lisuride's inhibitory effect on wet shakes persisted while escape attempts were actually potentiated with respect to control withdrawal rats. Increases in aggressive behavior were seen at all doses, and were dose-related. Haloperidol (0.3 mg/kg IP), administered 40 min before lisuride, did not modify the antagonistic effect on wet shakes, unlike sulpiride (40 mg/kg IP 30 min before lisuride), but at the same time blocked the increase in escape attempts and aggressiveness induced by lisuride. We suggest that lisuride modulates withdrawal signs by stimulation of dopamine receptors in the CNS. The effect of the dopamine mimetic N-n-propylnorapomorphine (NPA) on the same variables is reported as well as the influence of haloperidol on NPA, and a comparison between the effects of the two drugs is made.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00433735
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    Paper (German National Licenses)
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