Library

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    Steady-state kinetics of doxepin and imipramine in Saudi patients with interethnic comparison (1988)
    Springer
    Psychopharmacology 95 (1988), S. 63-67 
    Details
    ISSN: 1432-2072
    Keywords: Doxepin ; Imipramine ; Steady state ; Kinetics ; Interethnic difference
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The pharmacokinetics of doxepin (DX) was studied in 21 Saudi patients treated long term with oral doses of this tricyclic antidepressant agent. The mean (SEM) values of the dose-normalized steady-state concentration and the apparent clearance after oral administration of this drug were 25.8 (4.8) ng·ml-1/mg·kg-1 and 2.529 (0.342) l·h-1·kg-1, respectively. The pharmacokinetics of impramine (IMI) was also studied in 30 Saudi patients who received oral doses of this drug for long durations. The mean dose-normalized steady-state concentration of IMI was 68.3 (19.7) ng·ml-1/mg·kg-1, and the mean apparent clearance after oral administration of IMI was 1.619 (0.353) l·h-1·kg-1. The mean (SEM) ratio of the steady-state concentration of the metabolite desipramine (DES) to that of IMI (DES/IMI) was 0.873 (0.151). Using this value and the ratio of the mean apparent clearance after oral administration (TCL) of DES to that of IMI, the fraction of IMI metabolized to DES was calculated to be 0.489. The TCL of DES was estimated from data obtained for three additional patients who received oral doses of this drug for long durations. A mean value of 0.907 (0.351) l·h-1·kg-1 was obtained.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00212768
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Determination of Acrolein in Urine by Liquid Chromatography and Fluorescence Detection of Its Quinoline Derivative (1993)
    Springer
    Pharmaceutical research 10 (1993), S. 1587-1590 
    Details
    ISSN: 1573-904X
    Keywords: liquid chromatography ; derivatization ; cyclophosphamide metabolites ; therapeutic monitoring ; bone marrow transplant ; cancer
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract We describe an assay for acrolein in urine, employing derivatization with m-aminophenol in the presence of ferrous sulfate solution in sulfuric acid. The derivative (7-OH quinoline; DER) and the internal standard (quinine-bisulfate; IS) were separated on a l0-µm particle, 8 mm × 10-cm C18 cartridge in conjunction with a radial compression system using a mixture of 0.05 M dibasic ammonium phosphate solution (pH 2.5):acetonitrile:methanol (92:6:2) at a flow rate of 3 mL/min as a mobile phase. The effluent was monitored fluorometrically at excitation and emission wavelengths of 360 and 495 nm, respectively. The retention times of DER and IS under these conditions were 4.3 and 26 min, respectively, and no interference in the assay from any endogenous substance or other concomitantly used drug was observed. The assay was highly linear (r〉 0.994) in the range 1–20 µg/mL of acrolein in urine (CV at different concentrations, ≤7.9%). This method can serve to monitor acrolein pharmacokinetics in patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1018964401677
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...