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  • Immunohistochemistry  (2)
  • Intestinal smooth muscle  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Immunohistochemical localization of mitogen-activated protein kinase (MAPK) family and morphological changes in rat heart after ischemia-reperfusion injury (2000)
    Springer
    Medical electron microscopy 33 (2000), S. 74-81 
    Details
    ISSN: 1437-773X
    Keywords: Key words Mitogen-activated protein kinase (MAPK) ; Ischemia reperfusion injury ; Heart ; Ultrastructure ; Immunohistochemistry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The mitogen-activated protein kinase (MAPK) family is considered to be activated by stress, but the role of the MAPK family is still unknown in cardiac pathology. In the present study, not only the localization of MAPKs such as the extracellular responsive kinase (ERK), c-jun N-terminal kinase (JNK), and p38 MAPK (p38), but also ultrastructural changes were investigated in the ischemia-reperfusion model of Wistar rats. At 5, 10, 30, 60, and 180 min reperfusion after 30 min ischemia by occluding the coronary artery, the expression of these MAPKs was increased in blood vessels and cardiomyocytes by Western blotting and immunohistochemical methods. In addition, after ischemia reperfusion, various ultrastructural changes such as decreased glycogen granules, mitochondrial swelling, and myolysis were observed in the blood vessels and cardiomyocytes. These results suggest that protein kinases may regulate numerous biological processes, including the regulation of contraction and ion transport.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s007950070005
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Mitochondrial encephalomyopathy with lactic acidosis and stroke like episodes (MELAS) with prominent degeneration of the intestinal wall and cactus-like cerebellar pathology (2000)
    Springer
    Acta neuropathologica 100 (2000), S. 712-717 
    Details
    ISSN: 1432-0533
    Keywords: Key words Mitochondrial encephalomyopathy with ; lactic acidosis and stroke-like episodes ; Mitochondrial neurogastrointestinal encephalomyopathy ; 3243 point mutation ; Intestinal smooth muscle ; Copper deficiency
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A 67-year-old woman had frequent subacute ileus, hearing difficulty, muscle atrophy and stroke-like episodes. Computed tomography revealed multiple low-density areas, which did not correlate with the vascular supply, in the cerebral cortex. She had metabolic disturbance comprising lactic acidosis and elevated pyruvate level. Her skeletal muscle biopsy specimen showed ragged-red fibers, and mitochondrial DNA analysis revealed a point mutation at position 3243, findings consistent with MELAS. Examination of her small intestine revealed a necrotic zone and numerous abnormal large mitochondria in the smooth muscle cells, vascular media and endothelium, and intestinal ganglion cells. The cerebral cortex showed multiple microcystic necrotic foci in cerebral cortex. Cactus-like pathology resembling the changes associated with Menkes’ kinky hair disease and torpedoes were observed in the cerebellar Purkinje cells. The intestinal dysmotility due to MELAS and cerebellar changes were presumed to be associated with a disturbance of copper metabolism.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004010000209
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Solitary fibrous tumor of the pleura: report of a case with immunohistochemical and ultrastructural study (1998)
    Springer
    Medical molecular morphology 31 (1998), S. 147-150 
    Details
    ISSN: 1860-1499
    Keywords: Solitary fibrous tumor of the pleura ; Mesenchymal cell ; Immunohistochemistry ; CD 34 ; Ultrastructure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A solitary fibrous tumor of the pleura (SFTP) in a 37-year-old woman was reported as a rare pleural tumor based on morphological, immunohistochemical, and electron microscopic studies. The results showed that the tumor was composed of spindle-shaped cells forming fascicular and interlacing patterns with a mixture of mature collagen. The tumor cells coexpressed vimentin and CD34 and lacked cytokeratin reactivity. Ultrastructurally, there were abundant collagenous fibrillae surrounding spindle-shaped cells in which the junctional complex, basement membrane-like structure, and microvilli were not seen. From literature review and observation of the morphological features around the tumor, we consider that the tumor originated from the stromal cells subjacent to the mesothelium.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01553783
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    Paper (German National Licenses)
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