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  • Incisor growth  (1)
  • Prolactin  (1)
  • mania  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Acetylcholine and affective disorder (1987)
    Springer
    Journal of neural transmission 70 (1987), S. 295-312 
    Details
    ISSN: 1435-1463
    Keywords: Cholinomimetics ; depression ; mania ; sleep ; neuroendocrine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We reviewed the evidence for involvement of central cholinergic neurons in affective disorder. Cholinomimetics inhibit speech, thought, and activity in most subjects, decrease manic symptoms and, in some affective disorder patients, produce depressive symptoms. Cholinomimetics also cause ACTH and cortisol secretion and decrease latency to REM sleep. It is unclear whether cholinomimetics are specifically “antimanic” or “depressogenic” or whether their fundamental effect is nonspecific behavioral inhibition; whether the observed effects of cholinomimetics are mediated largely through cholinergic pathways, are secondary to changes in other neurotransmitters or are part of a nonspecific stress response. The suggestion that anticholinergic agents have mood elevating properties has not yet been subjected to controlled investigation. Although the proposal that affective disorders involve cholinergic neurons has received some support from clinical investigation further research is required to substantiate the intriguing observations to date and to clarify the physiologic and psychologic processes mediating them.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01253604
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Incorporation of tetracycline into impeded and unimpeded mandibular incisors of the mouse (1978)
    Springer
    Calcified tissue international 26 (1978), S. 29-31 
    Details
    ISSN: 1432-0827
    Keywords: Tetracycline ; Incisor growth ; Incisor unimpeded eruption
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Summary Twenty-four hours after a tetracycline injection, the unimpeded, and more rapidly erupting, mouse mandibular incisor contained 20% to 44% more tetracycline than the contralateral, uncut incisor. It was concluded that the increased tetracycline incorporation reflected a higher rate of mineralization associated with faster tooth formation in the unimpeded tooth. By measuring the amount of tetracycline which became incorporated at different times after an incisor was shortened, it was possible to investigate an early stage of the response of the incisor to cutting. A significant increase in the capacity of the tooth to incorporate tetracycline was detectable 4 h after shortening the tooth, and this was maximal after another 4 h.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02013230
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Stability of serum neuroleptic and prolactin concentrations during short- and long-term treatment of schizophrenic patients (1987)
    Springer
    Psychopharmacology 93 (1987), S. 237-242 
    Details
    ISSN: 1432-2072
    Keywords: Tolerance ; Haloperidol ; Thioridazine ; Prolactin ; Serum levels
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The potential importance of neuroleptic activity measures in the management of schizophrenia warrants attention to the methods for assessing neuroleptic bioactivity and stability of neuroleptic bioactivity over time. We have carried out measurements of serum neuroleptic and prolactin concentrations in 18 schizophrenic patients treated with haloperidol or thioridazine for up to 1 year. Serum neuroleptic levels were measurd by a radioreceptor assay using porcine striatum. The lower limit of sensitivity of the assay was 0.6 ng haloperidol/ml, the intra- and interassay coefficients of variation 3 and 9%, respectively. A linear correlation was observed between haloperidol dose (5–30 mg/d) and serum neuroleptic activity (r=0.706, P〈0.001) and a curvilinear relationship between thioridazine dose (50–600 mg/d) and serum neuroleptic activity in schizophrenic outpatients. There was a positive correlation between serum neuroleptic and prolactin concentrations for the patients taking haloperidol (r=0.620, P〈0.001) or thioridazine (r=0.542, P〈0.001). In patients taking a constant dose of haloperidol or thioridazine for up to 1 year serum neuroleptic activity remained stable, suggesting the absence of metabolic tolerance; the observation of a decrease of 38±16% (mean ± SD) in serum prolactin concentrations in patients treated with haloperidol but no prolactin decrease with thioridazine suggests that under certain neuroleptic treatment conditions a functional tolerance develops in the tuberoinfundibular dopamine system.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00179941
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    Paper (German National Licenses)
    Fulltext
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