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  • 1
    Electronic Resource
    Electronic Resource
    Blood flow and transport of free fatty acids in striated muscle under chronic ischemia (1976)
    Springer
    Pflügers Archiv 367 (1976), S. 49-53 
    Details
    ISSN: 1432-2013
    Keywords: Rat tibialis muscle ; Free fatty acids ; Transport outflow ; Inflow rate ; Blood flow
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Three weeks of ischemia of the right hind limb in rat produced by ligature and severing of the right common iliac artery, resulted in changes in FFA transport and blood flow in the regenerating tibialis muscle. FFA transport was measured using i.v. administered palmitate-1-14C bound to albumin. Uptake of palmitate-1-14C or86Rb 90 s after i.v. administration was decreased in ischemic tibialis muscle, whereas no apparent effect of ischemia on the contralateral muscle was seen. Plasma FFA outflow rate measured according Beker and Rostami was not affected by the presence of an ischemic extremity in comparison with control animals. The plasma FFA inflow rate into the ischemic muscle was markedly decreased to values of 6.5 mμmoles FFA/min/g whereas in control animals values were 18.8 mμmoles FFA/min/g wet tissue. Decreased FFA inflow rate to the ischemic tibialis muscle was due to the decreased radioactivity of palmitate-1-14C in the muscle under the conditions of a constant plasma FFA pool. Differences in the uptake of palmitate-1-14C in tibialis muscle were dependent upon the muscle blood flow, which was markedly decreased in the ischemic muscle on indirect measurement with86Rb or with the133Xe clearance.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00583656
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    The effect of anabolic hormone 19-nortestosterone propionate on the metabolism of striated muscle during experimental ischaemia (1976)
    Springer
    Pflügers Archiv 361 (1976), S. 159-163 
    Details
    ISSN: 1432-2013
    Keywords: Striated muscle ; Ischaemia ; Red and white fibres ; Enzymes ; Anabolic hormones
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The effect of the anabolic hormone 19-nortestosterone propionate (Superanabolon Spofa) on the metabolism of chronically ischaemic striated muscle (anterior tibial m.) was studied in a described model in the rat. Metabolic changes were estimated in terms of the activities of a number of enzymes in muscle fibres. Enzyme activities (AcP, ATPase, CE, LDH, MDH) were determined both biochemically and histochemically excepting SDH, which was determined only by the histochemical way. Morphological changes were investigated by routine histology. Administration of 19-nortestosterone propionate prevented enzymatic changes which are typical for chronic ischaemia, primarily the decrease in the activities of dehydrogenases of Krebs' cycle tricarboxylic acides (MDH, SDH). In addition, the ratio of red to white muscle fibres increased. Administration of anabolic hormone has a similar favourable action on ischaemic muscle as training, studied previously.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00583460
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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