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  • Inhibitory activity  (1)
  • Tribal population  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Urological research 15 (1987), S. 105-108 
    ISSN: 1434-0879
    Keywords: Sodium ; Inhibitory activity ; Oxalates ; Phosphates ; Calcium ; Calculi
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary the effect of changes in urinary sodium, induced by dietary manipulation in normal subjects (NS) and in stone formers (SF) was studied by observing crytalluria qualitatively and by determining calcium, oxalate and phosphate crystallization quantitatively in an experimental model. In SF the calcium crystallization was significantly higher than in NS at all the three levels of urinary sodium studied. However, no difference was observed in oxalate and phosphate crystallization rates between these two groups. Calcium and oxalate (p〈 0.05) and oxalate and phosphate (p〈 0.001) were found to be correlated in NS but were non-significant in SF. The wide changes in the urinary sodium induced by dietary changes did not influence the crystallization rate of calcium, nor of oxalate and phosphate in NS as well as in SF. The results suggested that a sodium intake with lower and upper limits of 124 mg and 6,009 mg respectively did not act as “inhibitor” of crystallization rate nor did it induce hypercalciuria severe enough to pose a “risk” of stone formation. The results did not suggest that a high urinary sodium increases the solubility of calcium phosphate.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1434-0879
    Keywords: Hyperoxaluria ; Nephrolithiasis ; Diet ; Hypercalciuric ; Tribal population
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The nutrient intake of 69 stone formers (SFs) from three subsets of the local population (urban 22, rural tribal 22 and rural nontribal 25) and 69 age, sex, weight and socioeconomically matched control subjects (NSs) (urban 20, rural tribal 22 and rural nontribal 27) was studied. Simultaneously their timed 24-h urine samples collected over a similar period were analyzed. In general caloric and protein intake was low in all the groups but was strikingly low in the rural subjects. Intake of all nutrients was lowest in the tribal group. Although no difference was observed in diet between NSs and SFs in the same population subjects, SFs had higher urinary excretion of oxalic acid and calcium and lower excretion of citric acid and excreted more saturated urine. Notably magnesium intake was normal in both NSs and SFs, but mean excretion of magnesium was lower than normal in all the groups, suggesting its defective absorption. The influence of dietary intake of protein, carbohydrate, fat, fiber, calcium and oxalic acid on urinary excretion of calcium, oxalic acid, uric acid, inorganic phosphorus, magnesium and citric acid was examined using the chi-square test. No association was observed, thus suggesting that this low nutrient intake did not influence the lithogenic process. Thus, the overall observations suggest: (a) poor nutrition, (b) no effect of diet on urinary stone disease, (c) no difference in the nutrient intake between NSs and SFs and (d) a higher excretion of promoters and a lower excretion of inhibitors in SFs than in NSs.
    Type of Medium: Electronic Resource
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